Disease relevance of COX10

• COX10 codes for a protein homologous to the ORF1 product of Paracoccus denitrificans and is required for the synthesis of yeast cytochrome oxidase [1].
• B. subtilis CtaB, which is homologous to Saccharomyces cerevisiae COX10 and E. coli CyoE, also has a role in haem A synthesis and seems to be required for both cytochrome a and cytochrome o synthesis [2].

High impact information on COX10

• In this and in other respects cox11 and cox10 mutants have very similar phenotypes [3].
• Mutation analysis followed by a complementation study in yeast permitted us to ascribe the COX deficiency to a homozygous missense mutation in the COX10 gene [4].
• Based on the nucleotide sequence of COX10, the primary translation product has an Mr of 52,000 [1].
• The wild type COX10 gene has been cloned by transformation of a mutant from complementation group G19 with a yeast genomic library [1].
• Genes homologous to COX10 are present in at least four different bacterial cytochrome oxidase operons [5].

Anatomical context of COX10

• COX10 and COX11 are nuclear genes of Saccharomyces cerevisiae whose products are localized in mitochondria and are required for the synthesis of cytochrome oxidase [5].

Other interactions of COX10

• On the functions of the yeast COX10 and COX11 gene products [5].

Analytical, diagnostic and therapeutic context of COX10

• The two enzymes responsible for the conversion of heme B to heme A, heme O synthase (HOS) and heme A synthase (HAS), were separately genomically epitope-tagged in Saccharomyces cerevisiae, and their expression under various copper conditions was quantified by Western blot analysis [6].

References