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Gene Review

KIP2  -  Kip2p

Saccharomyces cerevisiae S288c

Synonyms: Kinesin-like protein KIP2, P2581, YPL155C
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High impact information on KIP2

  • This movement is dependent upon the microtubule motor protein Kip2 [1].
  • The observation that deletion of KIP2 could also suppress the inviability of dyn1Delta kar3Delta cells suggests that kinesin-related Kar3p also contributes to spindle positioning [2].
  • Likewise, induced expression of KIP2 caused spindles to mislocalize in cells deficient for dynein and Kip3p [2].
  • Most significantly, the deletion of KIP2 greatly suppressed the spindle localization defect and slow growth exhibited by dyn1 kip3 cells [2].
  • We identified two new Saccharomyces cerevisiae kinesin-related genes, KIP1 and KIP2, using polymerase chain reaction primers corresponding to highly conserved regions of the kinesin motor domain [3].

Biological context of KIP2

  • Localization studies found Kip2p exclusively on cytoplasmic microtubules throughout the cell cycle, whereas GFP-Kip3p localized to both spindle and cytoplasmic microtubules [4].
  • Loss of both the Kip2p and Kar3p motors together in the same cell produces an intermediate phenotype, suggesting that these two motors act in opposition to control cytoplasmic microtubule density [5].
  • A Kip2p-GFP fusion from single gene expression is most concentrated at the spindle poles, as shown previously for an epitope tagged Kar3p-HA, suggesting both of these motors act from the minus ends of the microtubules to influence microtubule numbers [5].

Anatomical context of KIP2

  • Others operate on the cytoplasmic microtubules to effect spindle and nuclear positioning within the cell (dynein and kinesin-related Kip2p, Kip3p and Kar3p) [6].

Physical interactions of KIP2


Other interactions of KIP2

  • Our findings indicate that Kip2p participates in normal spindle positioning but antagonizes a positioning mechanism acting in dyn1 kip3 cells [2].
  • As with Bik1, the targeting of dynein to the microtubule plus end requires Kip2 [7].


  1. Yeast Cdk1 translocates to the plus end of cytoplasmic microtubules to regulate bud cortex interactions. Maekawa, H., Usui, T., Knop, M., Schiebel, E. EMBO J. (2003) [Pubmed]
  2. Mitotic spindle positioning in Saccharomyces cerevisiae is accomplished by antagonistically acting microtubule motor proteins. Cottingham, F.R., Hoyt, M.A. J. Cell Biol. (1997) [Pubmed]
  3. Kinesin-related proteins required for assembly of the mitotic spindle. Roof, D.M., Meluh, P.B., Rose, M.D. J. Cell Biol. (1992) [Pubmed]
  4. The kinesin-related proteins, Kip2p and Kip3p, function differently in nuclear migration in yeast. Miller, R.K., Heller, K.K., Frisèn, L., Wallack, D.L., Loayza, D., Gammie, A.E., Rose, M.D. Mol. Biol. Cell (1998) [Pubmed]
  5. The Kar3p and Kip2p motors function antagonistically at the spindle poles to influence cytoplasmic microtubule numbers. Huyett, A., Kahana, J., Silver, P., Zeng, X., Saunders, W.S. J. Cell. Sci. (1998) [Pubmed]
  6. Mitotic motors in Saccharomyces cerevisiae. Hildebrandt, E.R., Hoyt, M.A. Biochim. Biophys. Acta (2000) [Pubmed]
  7. Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation. Carvalho, P., Gupta, M.L., Hoyt, M.A., Pellman, D. Dev. Cell (2004) [Pubmed]
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