Disease relevance of ELP4

• Deletions of both TOT6 and TOT7 result in the complex tot phenotype, including resistance to zymocin, thermosensitivity, slow growth and hypersensitivity towards drugs, thus reinforcing the notion that TOT/Elongator may be crucial in signalling zymocicity [1].

High impact information on ELP4

• Disruption of the two nonessential new Elongator-encoding genes, ELP4 and ELP6, caused the same phenotypes observed with knockouts of the original Elongator-encoding genes [2].
• Purification of Elongator in higher salt concentrations served to demonstrate that the complex could be separated into two subcomplexes: one consisted of Elp1, -2, and -3, and the other consisted of Elp4, -5, and -6 [2].
• Elp2 and Elp4 were largely dispensable for the association of Elongator with nascent RNA transcript in vivo.In contrast, Elongator-RNA interaction requires the Elp3 protein [3].
• The induction of TSA2 by H(2)O(2) is also mediated in part through Hap1p [4].
• Elongator subcomplex components Elp4p and Elp6p are shown to be homologues of ATPases, yet with substitutions of amino acids critical for ATP hydrolysis, and novel orthologues of Elp5p are detectable in human, and other animal, sequences [5].

References