The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ARL3  -  Arf family GTPase ARL3

Saccharomyces cerevisiae S288c

Synonyms: ADP-ribosylation factor-like protein 3, ARP1, Arf-like GTPase 3, YPL051W
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ARL3

  • The GTPase Arl3p is required to recruit a second GTPase, Arl1p, to the Golgi in Saccharomyces cerevisiae [1].
  • Targeting of Arl3p also requires a Golgi membrane protein Sys1p [1].
  • We demonstrate that acetylation of the N-terminal methionine of Arl3p requires the NatC N(alpha)-acetyltransferase and that this modification is required for its Golgi localization [2].

Anatomical context of ARL3

  • GFP-GRIP reporters were localized to the cytosol in cells lacking either of two ARF-like (ARL) GTPases, Arl1p and Arl3p [3].

Regulatory relationships of ARL3


Other interactions of ARL3

  • The similar requirements for localization of GRIP domains from yeast, mouse, and human when expressed in yeast, and the presence of Arl1p and Arl3p homologs in these species, suggest that this is an evolutionarily conserved mechanism [3].


  1. Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p. Behnia, R., Panic, B., Whyte, J.R., Munro, S. Nat. Cell Biol. (2004) [Pubmed]
  2. Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p. Setty, S.R., Strochlic, T.I., Tong, A.H., Boone, C., Burd, C.G. Nat. Cell Biol. (2004) [Pubmed]
  3. Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3. Setty, S.R., Shin, M.E., Yoshino, A., Marks, M.S., Burd, C.G. Curr. Biol. (2003) [Pubmed]
WikiGenes - Universities