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ARL3  -  Arf family GTPase ARL3

Saccharomyces cerevisiae S288c

Synonyms: ADP-ribosylation factor-like protein 3, ARP1, Arf-like GTPase 3, YPL051W
 
 
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High impact information on ARL3

  • The GTPase Arl3p is required to recruit a second GTPase, Arl1p, to the Golgi in Saccharomyces cerevisiae [1].
  • Targeting of Arl3p also requires a Golgi membrane protein Sys1p [1].
  • We demonstrate that acetylation of the N-terminal methionine of Arl3p requires the NatC N(alpha)-acetyltransferase and that this modification is required for its Golgi localization [2].
 

Anatomical context of ARL3

  • GFP-GRIP reporters were localized to the cytosol in cells lacking either of two ARF-like (ARL) GTPases, Arl1p and Arl3p [3].
 

Regulatory relationships of ARL3

 

Other interactions of ARL3

  • The similar requirements for localization of GRIP domains from yeast, mouse, and human when expressed in yeast, and the presence of Arl1p and Arl3p homologs in these species, suggest that this is an evolutionarily conserved mechanism [3].

References

  1. Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p. Behnia, R., Panic, B., Whyte, J.R., Munro, S. Nat. Cell Biol. (2004) [Pubmed]
  2. Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p. Setty, S.R., Strochlic, T.I., Tong, A.H., Boone, C., Burd, C.G. Nat. Cell Biol. (2004) [Pubmed]
  3. Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3. Setty, S.R., Shin, M.E., Yoshino, A., Marks, M.S., Burd, C.G. Curr. Biol. (2003) [Pubmed]
 
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