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Gene Review

PDH1  -  Pdh1p

Saccharomyces cerevisiae S288c

Synonyms: LPZ2W, YP9723.02, YPR002W
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Disease relevance of PDH1


High impact information on PDH1

  • Rephosphorylation of Pdh1p and Cdr1p was protein kinase A inhibitor-sensitive but responded differentially to Tpk isoforms, stressors, and glucose concentration [2].
  • This suggests that phosphorylation of Pdh1p may be required for efficient coupling of NTPase activity with drug efflux [3].
  • In 4 of these 10 isolates PDH1 was similarly upregulated, and in the remainder it was upregulated three- to fivefold, while ERG11 expression was minimally changed [4].
  • Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata [5].
  • PDH1, CgCDR1 and PDR5 have striking similarities in function and regulation [6].

Biological context of PDH1

  • Expression of PDH1 in a C. glabrata cgcdr1::ura3 pdh1Delta::ura3 mutant using a multicopy plasmid almost completely restored the wild-type phenotype, showing that PDH1 at higher levels of expression can replace CgCDR1 [6].

Associations of PDH1 with chemical compounds


  1. Pdr1 regulates multidrug resistance in Candida glabrata: gene disruption and genome-wide expression studies. Vermitsky, J.P., Earhart, K.D., Smith, W.L., Homayouni, R., Edlind, T.D., Rogers, P.D. Mol. Microbiol. (2006) [Pubmed]
  2. Phosphorylation of candida glabrata ATP-binding cassette transporter Cdr1p regulates drug efflux activity and ATPase stability. Wada, S., Tanabe, K., Yamazaki, A., Niimi, M., Uehara, Y., Niimi, K., Lamping, E., Cannon, R.D., Monk, B.C. J. Biol. Chem. (2005) [Pubmed]
  3. Candida glabrata ATP-binding cassette transporters Cdr1p and Pdh1p expressed in a Saccharomyces cerevisiae strain deficient in membrane transporters show phosphorylation-dependent pumping properties. Wada, S., Niimi, M., Niimi, K., Holmes, A.R., Monk, B.C., Cannon, R.D., Uehara, Y. J. Biol. Chem. (2002) [Pubmed]
  4. Azole resistance in Candida glabrata: coordinate upregulation of multidrug transporters and evidence for a Pdr1-like transcription factor. Vermitsky, J.P., Edlind, T.D. Antimicrob. Agents Chemother. (2004) [Pubmed]
  5. Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata. Miyazaki, H., Miyazaki, Y., Geber, A., Parkinson, T., Hitchcock, C., Falconer, D.J., Ward, D.J., Marsden, K., Bennett, J.E. Antimicrob. Agents Chemother. (1998) [Pubmed]
  6. Function of Candida glabrata ABC transporter gene, PDH1. Izumikawa, K., Kakeya, H., Tsai, H.F., Grimberg, B., Bennett, J.E. Yeast (2003) [Pubmed]
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