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Gene Review

YOP1  -  Yop1p

Saccharomyces cerevisiae S288c

Synonyms: Protein YOP1, YIP1 partner protein 1, YIP2, YP9367.08, YPR028W, ...
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High impact information on YOP1

  • (2006) report that two membrane proteins, Rtn4a/NogoA and DP1/Yop1p, are responsible for the generation of tubular morphology in the endoplasmic reticulum (ER) [1].
  • Disruption of YOP1 has no apparent effect on cell viability, while overexpression results in cell death, accumulation of internal cell membranes, and a block in membrane traffic [2].
  • Yop1p is a membrane protein with a hydrophilic region at its N terminus through which it interacts specifically with the cytosolic domain of Yip1p [2].
  • Our data demonstrate that Yop1p negatively regulates cell growth [2].
  • The yeast double mutant of yop1 and sey1 is defective in vesicular traffic as evidenced by the accumulation of transport vesicles and the decrease in invertase secretion [3].

Anatomical context of YOP1

  • Receptor Expression-Enhancing Proteins (REEP) 3 is one of the six human homologs of yeast Yop1p, a probable regulator of cellular vesicle trafficking between the endoplasmatic reticulum and the Golgi network [4].

Other interactions of YOP1

  • The yeast (Saccharomyces cerevisiae) HVA22 homolog, Yop1p, has been shown to interact with the GTPase-interacting protein, Yip1p [3].


  1. How the ER stays in shape. Collins, R.N. Cell (2006) [Pubmed]
  2. Yop1p, the yeast homolog of the polyposis locus protein 1, interacts with Yip1p and negatively regulates cell growth. Calero, M., Whittaker, G.R., Collins, R.N. J. Biol. Chem. (2001) [Pubmed]
  3. Function of a plant stress-induced gene, HVA22. Synthetic enhancement screen with its yeast homolog reveals its role in vesicular traffic. Brands, A., Ho, T.H. Plant Physiol. (2002) [Pubmed]
  4. Identification and characterization of the TRIP8 and REEP3 genes on chromosome 10q21.3 as novel candidate genes for autism. Castermans, D., Vermeesch, J.R., Fryns, J.P., Steyaert, J.G., Van de Ven, W.J., Creemers, J.W., Devriendt, K. Eur. J. Hum. Genet. (2007) [Pubmed]
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