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Gene Review

ATG19  -  Atg19p

Saccharomyces cerevisiae S288c

Synonyms: Autophagy-related protein 19, CVT19, Cytoplasm-to-vacuole targeting protein 19, O0980, YOL01, ...
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High impact information on ATG19

  • Cvt19 is a peripheral membrane protein that binds to the precursor form of the Cvt cargo protein aminopeptidase I (prAPI) and travels to the vacuole with prAPI [1].
  • Autophagy (Apg) and pexophagy, processes that use the majority of the same protein components as the Cvt pathway, do not require Cvt19 [1].
  • Ape1p and Ams1p bind to their receptor, Atg19p, in the cytosol to form a Cvt complex, which then associates with a membrane structure that envelops the complex before fusing with the vacuolar membrane [2].
  • Precursor Ape1 along with its receptor Atg19 forms the Cvt complex, which is transported to the pre-autophagosomal structure (PAS), the putative site of Cvt vesicle formation, in a process dependent on Atg11 [3].
  • Here, we show that the deubiquitinating enzyme Ubp3p interacts with Atg19p [2].

Associations of ATG19 with chemical compounds

  • Atg19p is ubiquitinated on two lysine residues, Lys(213) and Lys(216), which, when mutated, reduce the interaction of Atg19p with Ape1p [2].

Other interactions of ATG19

  • The deletion of APE1 or ATG19 compromised the organization of the pre-autophagosomal structure (PAS), a site that is thought to play a critical role in Cvt vesicle/autophagosome formation [4].
  • In particular, those factors are essential to correctly target the prApe1-Cvt19-Cvt9 complex to the preautophagosomal structure, the site of Cvt vesicle formation [5].
  • Furthermore, the perivacuolar compartment designates the initial site of membrane binding by the Apg/Cvt vesicle component Aut7, the Cvt cargo receptor Cvt19, and the Apg conjugation machinery, which functions in the de novo formation of vesicles [6].


  1. Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway. Scott, S.V., Guan, J., Hutchins, M.U., Kim, J., Klionsky, D.J. Mol. Cell (2001) [Pubmed]
  2. Atg19p ubiquitination and the cytoplasm to vacuole trafficking pathway in yeast. Baxter, B.K., Abeliovich, H., Zhang, X., Stirling, A.G., Burlingame, A.L., Goldfarb, D.S. J. Biol. Chem. (2005) [Pubmed]
  3. Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway. Yorimitsu, T., Klionsky, D.J. Mol. Biol. Cell (2005) [Pubmed]
  4. Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway. Shintani, T., Klionsky, D.J. J. Biol. Chem. (2004) [Pubmed]
  5. Vps51 is part of the yeast Vps fifty-three tethering complex essential for retrograde traffic from the early endosome and Cvt vesicle completion. Reggiori, F., Wang, C.W., Stromhaug, P.E., Shintani, T., Klionsky, D.J. J. Biol. Chem. (2003) [Pubmed]
  6. Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation. Kim, J., Huang, W.P., Stromhaug, P.E., Klionsky, D.J. J. Biol. Chem. (2002) [Pubmed]
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