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Gene Review

ISA2  -  Isa2p

Saccharomyces cerevisiae S288c

Synonyms: Iron-sulfur assembly protein 2, YP9499.22, YPR067W
 
 
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High impact information on ISA2

  • Role of Saccharomyces cerevisiae ISA1 and ISA2 in iron homeostasis [1].
  • However, Isa2p is present within the intermembrane space of the mitochondria [1].
  • Phenotypic defects associated with the absence of Grx5 are suppressed by overexpression of SSQ1 and ISA2, two genes involved in the synthesis and assembly of iron/sulfur clusters into proteins [2].
  • When Isa2p was depleted by regulated gene expression, mtDNA was maintained, but cells grew slowly on non-fermentable carbon sources [3].
 

Associations of ISA2 with chemical compounds

  • An inspection of Isa-like proteins from bacteria to mammals revealed three invariant cysteine residues, which in the case of Isa1p and Isa2p are essential for function and may be involved in iron binding [1].

References

  1. Role of Saccharomyces cerevisiae ISA1 and ISA2 in iron homeostasis. Jensen, L.T., Culotta, V.C. Mol. Cell. Biol. (2000) [Pubmed]
  2. Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes. Rodríguez-Manzaneque, M.T., Tamarit, J., Bellí, G., Ros, J., Herrero, E. Mol. Biol. Cell (2002) [Pubmed]
  3. Mitochondrial Isa2p plays a crucial role in the maturation of cellular iron-sulfur proteins. Pelzer, W., Mühlenhoff, U., Diekert, K., Siegmund, K., Kispal, G., Lill, R. FEBS Lett. (2000) [Pubmed]
 
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