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Gene Review

WSC4  -  Wsc4p

Saccharomyces cerevisiae S288c

Synonyms: Cell wall integrity and stress response component 4, YFW1, YHC8, YHL028W
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High impact information on WSC4

  • Disruption of YHC8, a member of the TSR1 gene family, reveals its direct involvement in yeast protein translocation [1].
  • Immunofluorescence experiments show that Yhc8p is localized in the endoplasmic reticulum [1].
  • We generated a null mutation in the S. cerevisiae YHC8 gene, the closest homologue to Y. lipolytica TSR1, and used different soluble (carboxypeptidase Y, alpha-factor, invertase) and membrane (dipeptidyl-aminopeptidase) secretory proteins to study its phenotype [1].
  • The YFW1 and YFW12 proteins are highly serine and threonine rich, and YFW1 contains a stretch of 28 hydrophobic residues, indicating that it may be a membrane protein [2].
  • In contrast, deletion of WSC4 enhances the sensitivity of the wsc1delta mutant to heat shock, ethanol, and a DNA-damaging drug, suggesting that WSC4 plays a role in the response to environmental stress but that its function may differ from those of the other WSC family members [3].

Biological context of WSC4


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