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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SNU13  -  RNA binding protein SNU13

Saccharomyces cerevisiae S288c

Synonyms: 13 kDa ribonucleoprotein-associated protein, Small nuclear ribonucleoprotein-associated protein 1, YEL026W
 
 
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High impact information on SNU13

  • Here we present a functional analysis of Snu13p in vivo, using a galactose inducible SNU13 strain to investigate the basis of three lethal mutations in Saccharomyces cerevisiae [1].
  • A structural, phylogenetic, and functional study of 15.5-kD/Snu13 protein binding on U3 small nucleolar RNA [2].
  • This motif is similar to the binding site of yeast ribosomal protein L30, the Snu13p binding sites found in U4 snRNA and box C/D snoRNAs, and two elements in 23S rRNA [3].
  • Snu13p initiates assembly of ribonucleoprotein particles by interacting with a conserved RNA motif called kink turn [4].
  • Snu13p is a bifunctional yeast protein involved in both messenger RNA splicing as well as ribosomal RNA maturation [4].

References

  1. Analysis of Snu13p mutations reveals differential interactions with the U4 snRNA and U3 snoRNA. Dobbyn, H.C., O'Keefe, R.T. RNA (2004) [Pubmed]
  2. A structural, phylogenetic, and functional study of 15.5-kD/Snu13 protein binding on U3 small nucleolar RNA. Marmier-Gourrier, N., Cléry, A., Senty-Ségault, V., Charpentier, B., Schlotter, F., Leclerc, F., Fournier, R., Branlant, C. RNA (2003) [Pubmed]
  3. The GA motif: an RNA element common to bacterial antitermination systems, rRNA, and eukaryotic RNAs. Winkler, W.C., Grundy, F.J., Murphy, B.A., Henkin, T.M. RNA (2001) [Pubmed]
  4. Structural comparison of yeast snoRNP and spliceosomal protein Snu13p with its homologs. Oruganti, S., Zhang, Y., Li, H. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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