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Gene Review

GLC3  -  1,4-alpha-glucan branching enzyme

Saccharomyces cerevisiae S288c

Synonyms: 1,4-alpha-glucan-branching enzyme, Glycogen-branching enzyme, YEL011W
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Disease relevance of GLC3

  • Human hepatoma cell line HepG2-derived cDNA libraries using the pAB23BXN yeast expression vector yielded four cDNAs capable of complementing the glc3::TRP1 glycogen branching enzyme mutation [1].

High impact information on GLC3

  • Indeed, glycogen branching activity was undetectable in extracts from a glc3-1p strain but was elevated in strains which expressed GLC3 from a high-copy-number plasmid [2].
  • Disruption of GLC3 yielded the glycogen-deficient phenotype, indicating that glycogen deficiency is the null phenotype [2].
  • From the data on GLC3, there may be a suppression of recombination near the chromosome V centromere, at least in some strains [3].


  1. Isolation of human glycogen branching enzyme cDNAs by screening complementation in yeast. Thon, V.J., Khalil, M., Cannon, J.F. J. Biol. Chem. (1993) [Pubmed]
  2. GLC3 and GHA1 of Saccharomyces cerevisiae are allelic and encode the glycogen branching enzyme. Rowen, D.W., Meinke, M., LaPorte, D.C. Mol. Cell. Biol. (1992) [Pubmed]
  3. Characterization of glycogen-deficient glc mutants of Saccharomyces cerevisiae. Cannon, J.F., Pringle, J.R., Fiechter, A., Khalil, M. Genetics (1994) [Pubmed]
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