Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

RPH1 - Rph1p

Saccharomyces cerevisiae S288c

Synonyms: DNA damage-responsive transcriptional repressor RPH1, YER169W

Kim, E.M. et al., Jang, Y.K. et al.

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High impact information on RPH1

In vitro footprinting and binding competition studies indicate that the sequence AG(4) (C(4)T) within URS(PHR1) is the binding site for Rph1p and Gis1p and suggests that at least one additional DNA binding component is present in the PRP complex [1].
Phosphorylation of Rph1, a damage-responsive repressor of PHR1 in Saccharomyces cerevisiae, is dependent upon Rad53 kinase [2].
Rph1 phosphorylation required the kinase activity of Rad53 since it was significantly decreased in rad53 checkpoint mutant [2].
In this report, we have demonstrated that the phosphorylation of Rph1 protein was increased in response to DNA damage [2].

Other interactions of RPH1

Rph1, a Cys2-His2 zinc finger protein, binds to an upstream repressing sequence of the photolyase gene PHR1, and represses its transcription in response to DNA damage in Saccharomyces cerevisiae [2].

References

RPH1 and GIS1 are damage-responsive repressors of PHR1. Jang, Y.K., Wang, L., Sancar, G.B. Mol. Cell. Biol. (1999) [Pubmed]
Phosphorylation of Rph1, a damage-responsive repressor of PHR1 in Saccharomyces cerevisiae, is dependent upon Rad53 kinase. Kim, E.M., Jang, Y.K., Park, S.D. Nucleic Acids Res. (2002) [Pubmed]

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