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Gene Review

OASL  -  2'-5'-oligoadenylate synthetase-like

Homo sapiens

Synonyms: 2'-5'-OAS-RP, 2'-5'-OAS-related protein, 2'-5'-oligoadenylate synthase-like protein, 59 kDa 2'-5'-oligoadenylate synthase-like protein, OASLd, ...
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High impact information on OASL


Associations of OASL with chemical compounds

  • Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor [6].

Other interactions of OASL

  • These findings link the p59 OASL with MBD1 transcriptional control in the context of an interferon-stimulated cell, and provide the basis for future studies to examine the functional role of this interaction [6].


  1. p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. Hartmann, R., Olsen, H.S., Widder, S., Jorgensen, R., Justesen, J. Nucleic Acids Res. (1998) [Pubmed]
  2. Dengue virus induces novel changes in gene expression of human umbilical vein endothelial cells. Warke, R.V., Xhaja, K., Martin, K.J., Fournier, M.F., Shaw, S.K., Brizuela, N., de Bosch, N., Lapointe, D., Ennis, F.A., Rothman, A.L., Bosch, I. J. Virol. (2003) [Pubmed]
  3. The Mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous oas1 genes in rodentia and artiodactyla. Perelygin, A.A., Zharkikh, A.A., Scherbik, S.V., Brinton, M.A. J. Mol. Evol. (2006) [Pubmed]
  4. Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. Yakub, I., Lillibridge, K.M., Moran, A., Gonzalez, O.Y., Belmont, J., Gibbs, R.A., Tweardy, D.J. J. Infect. Dis. (2005) [Pubmed]
  5. The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus. Hovnanian, A., Rebouillat, D., Levy, E.R., Mattei, M.G., Hovanessian, A.G. Genomics (1999) [Pubmed]
  6. Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. Andersen, J.B., Strandbygård, D.J., Hartmann, R., Justesen, J. Eur. J. Biochem. (2004) [Pubmed]
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