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Gene Review:

OASL - 2'-5'-oligoadenylate synthetase-like

Homo sapiens

Synonyms: 2'-5'-OAS-RP, 2'-5'-OAS-related protein, 2'-5'-oligoadenylate synthase-like protein, 59 kDa 2'-5'-oligoadenylate synthase-like protein, OASLd, ...

Andersen, J.B. et al., Yakub, I. et al., Hovnanian, A. et al., Perelygin, A.A. et al., Warke, R.V. et al., et al.

Perelygin, Zharkikh, Scherbik, Brinton,

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High impact information on OASL

p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family [1].
Tumor necrosis factor alpha, OASL, and MxA and h-IAP1 genes were induced within the first 8 to 12 h after infection, suggesting a direct effect of DV infection [2].
While two tandemly duplicated OAS-like (OASL) genes were identified in the dog genome, only a single OASL orthologue was found in both the cattle and the pig genomes [3].
However, comparison of the exonic sequences between case patients and control subjects identified 23 single nucleotide polymorphisms (SNPs), including a synonymous SNP in OASL exon 2 (rs3213545), in which the reference allele occurred at a higher frequency in case patients (P < .004) [4].
The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus [5].

Associations of OASL with chemical compounds

Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor [6].

Other interactions of OASL

These findings link the p59 OASL with MBD1 transcriptional control in the context of an interferon-stimulated cell, and provide the basis for future studies to examine the functional role of this interaction [6].

References

p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. Hartmann, R., Olsen, H.S., Widder, S., Jorgensen, R., Justesen, J. Nucleic Acids Res. (1998) [Pubmed]
Dengue virus induces novel changes in gene expression of human umbilical vein endothelial cells. Warke, R.V., Xhaja, K., Martin, K.J., Fournier, M.F., Shaw, S.K., Brizuela, N., de Bosch, N., Lapointe, D., Ennis, F.A., Rothman, A.L., Bosch, I. J. Virol. (2003) [Pubmed]
The Mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous oas1 genes in rodentia and artiodactyla. Perelygin, A.A., Zharkikh, A.A., Scherbik, S.V., Brinton, M.A. J. Mol. Evol. (2006) [Pubmed]
Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. Yakub, I., Lillibridge, K.M., Moran, A., Gonzalez, O.Y., Belmont, J., Gibbs, R.A., Tweardy, D.J. J. Infect. Dis. (2005) [Pubmed]
The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus. Hovnanian, A., Rebouillat, D., Levy, E.R., Mattei, M.G., Hovanessian, A.G. Genomics (1999) [Pubmed]
Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. Andersen, J.B., Strandbygård, D.J., Hartmann, R., Justesen, J. Eur. J. Biochem. (2004) [Pubmed]

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OASL	Macaca mulatta
Oasl1	Mus musculus
OASL	Pan troglodytes
Oasl	Rattus norvegicus

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