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Gene Review

pilC  -  pseudo

Pseudomonas aeruginosa PAO1

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Disease relevance of pilC

  • The D. nodosus genes fimN, fimO, and fimP are homologs of the Pseudomonas aeruginosa fimbrial assembly genes, pilB, pilC, and pilD, respectively [1].

High impact information on pilC

  • These results indicate that M. xanthus pilB and pilC are required for pilus biogenesis, while pilT is required for assembled pili to play their role in social motility [2].
  • However, the fimN and fimO genes did not complement pilB or pilC mutants, respectively [1].
  • Type IV pilus genes pilA and pilC of Pseudomonas stutzeri are required for natural genetic transformation, and pilA can be replaced by corresponding genes from nontransformable species [3].
  • Products of three accessory genes, pilB, pilC, and pilD, are required for biogenesis of Pseudomonas aeruginosa pili [4].

Biological context of pilC


Associations of pilC with chemical compounds

  • The amounts of (3)H-labeled P. stutzeri DNA that were bound to competent parental cells and taken up were strongly reduced in the pilC and pilA mutants [3].

Analytical, diagnostic and therapeutic context of pilC

  • Insertions into pilC, however, resulted in decreased synthesis of PilD as determined by quantitation of PilD enzymatic activity in processing prepilin in vitro and by immunoassay [6].


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