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Gene Review

vanA  -  vanillate O-demethylase oxygenase

Pseudomonas aeruginosa PAO1

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Disease relevance of vanA

  • The overall organization of genes neighboring Acinetobacter vanA and vanB, including a putative transcriptional regulatory gene that is convergently transcribed and overlaps vanB, is conserved in Pseudomonas aeruginosa but has undergone radical rearrangement in other Pseudomonas species [1].
  • Primer/probe assays for real-time PCR (TaqMan) designed to quantitatively detect the antibiotic resistance genes bla(VIM), vanA, ampC, mecA, and taxon-specific 23S rDNA sequences for Pseudomonas aeruginosa and Enterococcus faecium/faecalis were tested for their sensitivity and amplification robustness [2].

High impact information on vanA

  • The vanA gene was localized to a plasmid of approximately 100 kb in VRSA and E. faecium isolates from the biofilm [3].
  • For the detection of the resistance genes bla(VIM), vanA, ampC, and mecA as well as the enterococci directed PCR only weak or no inhibition due to the impurities or wastewater DNA matrix were demonstrated for the applied target concentrations [2].


  1. Genetic analysis of a chromosomal region containing vanA and vanB, genes required for conversion of either ferulate or vanillate to protocatechuate in Acinetobacter. Segura, A., Bünz, P.V., D'Argenio, D.A., Ornston, L.N. J. Bacteriol. (1999) [Pubmed]
  2. Evaluation of inhibition and cross-reaction effects on real-time PCR applied to the total DNA of wastewater samples for the quantification of bacterial antibiotic resistance genes and taxon-specific targets. Volkmann, H., Schwartz, T., Kirchen, S., Stofer, C., Obst, U. Mol. Cell. Probes (2007) [Pubmed]
  3. High-Level Vancomycin-Resistant Staphylococcus aureus Isolates Associated with a Polymicrobial Biofilm. Weigel, L.M., Donlan, R.M., Shin, D.H., Jensen, B., Clark, N.C., McDougal, L.K., Zhu, W., Musser, K.A., Thompson, J., Kohlerschmidt, D., Dumas, N., Limberger, R.J., Patel, J.B. Antimicrob. Agents Chemother. (2007) [Pubmed]
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