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Gene Review

fur  -  ferric uptake regulator

Escherichia coli O157:H7 str. EDL933

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Disease relevance of fur


High impact information on fur

  • Reduction of the disulfide bridges causes only local structure variations, whereas zinc addition to reduced Fur induces protein dimerization [1].
  • Ferric uptake regulator (Fur) is a global bacterial regulator that uses iron as a cofactor to bind to specific DNA sequences [1].
  • Transcription of perR was autoregulated, and PerR repressed transcription of the iron homeostasis regulator Fur, which is a positive regulator of catalase expression [3].
  • Thus, these regulators may sense the physiological consequences of extraneous Fe concentrations, rather than the concentration of Fe per se, as happens in those bacteria (e.g. Escherichia coli) in which the ferric uptake regulator Fur is the global Fe-responsive gene regulator [4].

Analytical, diagnostic and therapeutic context of fur


  1. Structural changes of Escherichia coli ferric uptake regulator during metal-dependent dimerization and activation explored by NMR and X-ray crystallography. Pecqueur, L., D'Autréaux, B., Dupuy, J., Nicolet, Y., Jacquamet, L., Brutscher, B., Michaud-Soret, I., Bersch, B. J. Biol. Chem. (2006) [Pubmed]
  2. Functional characterization of the dimerization domain of the ferric uptake regulator (Fur) of Pseudomonas aeruginosa. Bai, E., Rosell, F.I., Lige, B., Mauk, M.R., Lelj-Garolla, B., Moore, G.R., Mauk, A.G. Biochem. J. (2006) [Pubmed]
  3. PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphylococcus aureus. Horsburgh, M.J., Clements, M.O., Crossley, H., Ingham, E., Foster, S.J. Infect. Immun. (2001) [Pubmed]
  4. The Rhizobium leguminosarum regulator IrrA affects the transcription of a wide range of genes in response to Fe availability. Todd, J.D., Sawers, G., Rodionov, D.A., Johnston, A.W. Mol. Genet. Genomics (2006) [Pubmed]
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