Disease relevance of NAV2

• By using the human neuroblastoma cell line, SH-SY5Y, we have identified an atRA-responsive gene (RAINB1: retinoic acid inducible in neuroblastoma cells) that is induced within 4 h after exposure of SH-SY5Y cells to atRA [1].
• HELAD1 was abundantly expressed in 16 of 20 colon cancers examined but hardly detectable in corresponding non-cancerous mucosae [2].
• Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas [2].
• Antigenic characterization of 94 additional influenza A viruses from the ducks showed four haemagglutinin subtypes (Hav1, Hav4, Hav5 and Hav7), an unclassified haemagglutinin, and six neuraminidase subtypes (N1, N2, Neq2, Nav1, Nav2 and Nav5) in various combinations, some of which are novel and have not previously been reported [3].

High impact information on NAV2

• RAINB1 is present on chromosome 11 and is spread over 38 exons, resulting in a putative ORF of 2,429 amino acids [1].
• Thus, RAINB1 may represent a critical downstream gene in atRA-mediated neurite outgrowth [1].
• A recombinant polypeptide representing the ATPases associated with cellular activities (AAA) domain of the HELAD1 product showed 3' to 5' helicase activity and exonuclease activity in vitro [2].
• The first exon of NAV1 arose through an ancient internal duplication of sequences that also gave rise to exon 8 of NAV3 and exon 7 of NAV2 [4].
• NAV1, NAV2, and NAV3 expression is detected in adult heart, kidney, and brain, respectively [4].

Other interactions of NAV2

• 1. NAV1 and NAV2 are expressed in the developing brain [4].

References