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Gene Review

NAV1  -  neuron navigator 1

Homo sapiens

Synonyms: DKFZp781D0314, FLJ12560, FLJ14203, KIAA1151, KIAA1213, ...
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Disease relevance of NAV1

  • Antigenic characterization of 94 additional influenza A viruses from the ducks showed four haemagglutinin subtypes (Hav1, Hav4, Hav5 and Hav7), an unclassified haemagglutinin, and six neuraminidase subtypes (N1, N2, Neq2, Nav1, Nav2 and Nav5) in various combinations, some of which are novel and have not previously been reported [1].
  • A virus (Hav6 Nav1, Hav6 Nl, Hav7 Neq2) as well as Newcastle disease virus [2].
  • The shifted steady-state inactivation shows similarities to that obtained from axotomized dorsal root ganglions, which were shown to upregulate Nav1 [3].
  • Two groups of antigenic recombinants Hav4N1 were obtained by recombination of human influenza virus H0N1 with two avian influenza viruses isolated from ducks in 1956 and terns in 1978 and possessing the same surface antigen Hav4 Nav1 [4].
  • Inherited erythromelalgia has recently been linked to mutations in the gene SCN9A, which encodes the voltage-gated sodium channel Nav1 [5].

High impact information on NAV1

  • Ca2+ has been proposed to regulate Na+ channels through the action of calmodulin (CaM) bound to an IQ motif or through direct binding to a paired EF hand motif in the Nav1 C terminus [6].
  • Total burst length of BM decreased with depolarization and was larger in failing compared to normal myocytes and Nav1 [7].
  • Inward current characteristics were also analysed in Xenopus laevis oocytes that heterologously expressed the human sodium channel alpha-subunit Nav1 [8].
  • The binding of flecainide to open channels was further investigated in a non-inactivating mutant of Nav1 [9].
  • This region contains several important phosphorylation sites that modulate Na+ channel kinetics in related sodium channels, i.e. Nav1 [10].

Biological context of NAV1

  • The results of hemagglutination and neuraminidase-inhibition tests with monospecific antisera to the isolated surface antigens showed that the isolates possessed Hav4 hemagglutinin and Nav1 neuraminidase subunits both of which were closely related to the corresponding antigens of A/duck/Czech/56 (Hav4 Nav1) [11].

Anatomical context of NAV1


Associations of NAV1 with chemical compounds

  • Here, we studied the effect of such prolonged exposure to gabapentin on a rat sodium channel, Nav1 [13].

Other interactions of NAV1

  • 1. NAV1 and NAV2 are expressed in the developing brain [14].


  1. Novel influenza A viruses isolated from Canadian feral ducks: including strains antigenically related to swine influenza (Hsw1N1) viruses. Hinshaw, V.S., Webster, R.G., Turner, B. J. Gen. Virol. (1978) [Pubmed]
  2. Ortho- and paramyxoviruses from migrating feral ducks: characterization of a new group of influenza A viruses. Webster, R.G., Morita, M., Pridgen, C., Tumova, B. J. Gen. Virol. (1976) [Pubmed]
  3. Upregulation of persistent and ramp sodium current in dorsal horn neurons after spinal cord injury. Lampert, A., Hains, B.C., Waxman, S.G. Experimental brain research. Experimentelle Hirnforschung. Exp??rimentation c??r??brale. (2006) [Pubmed]
  4. Studies on some genetic properties of antigenic recombinants of influenza viruses. Podchernyaeva RYa, n.u.l.l., Döhner, L., Herrmann, R.M., Blinova, V.K., Ivanova, V.T. Acta Virol. (1982) [Pubmed]
  5. Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav1.7. Han, C., Lampert, A., Rush, A.M., Dib-Hajj, S.D., Wang, X., Yang, Y., Waxman, S.G. Molecular pain (2007) [Pubmed]
  6. Calmodulin mediates Ca2+ sensitivity of sodium channels. Kim, J., Ghosh, S., Liu, H., Tateyama, M., Kass, R.S., Pitt, G.S. J. Biol. Chem. (2004) [Pubmed]
  7. A multi-modal composition of the late Na+ current in human ventricular cardiomyocytes. Maltsev, V.A., Undrovinas, A.I. Cardiovasc. Res. (2006) [Pubmed]
  8. Occurrence of a tetrodotoxin-sensitive calcium current in rat ventricular myocytes after long-term myocardial infarction. Alvarez, J.L., Salinas-Stefanon, E., Orta, G., Ferrer, T., Talavera, K., Galán, L., Vassort, G. Cardiovasc. Res. (2004) [Pubmed]
  9. State-dependent trapping of flecainide in the cardiac sodium channel. Ramos, E., O'leary, M.E. J. Physiol. (Lond.) (2004) [Pubmed]
  10. Distribution and functional characterization of human Nav1.3 splice variants. Thimmapaya, R., Neelands, T., Niforatos, W., Davis-Taber, R.A., Choi, W., Putman, C.B., Kroeger, P.E., Packer, J., Gopalakrishnan, M., Faltynek, C.R., Surowy, C.S., Scott, V.E. Eur. J. Neurosci. (2005) [Pubmed]
  11. Isolation of influenza A virus from budgerigars and its serological characterization. Yamamoto, H., Otsuki, K., Tsubokura, M. Microbiol. Immunol. (1979) [Pubmed]
  12. Dysregulation of sodium channel gating in critical illness myopathy. Teener, J.W., Rich, M.M. J. Muscle Res. Cell. Motil. (2006) [Pubmed]
  13. Inhibition of the rat brain sodium channel Nav1.2 after prolonged exposure to gabapentin. Liu, Y., Qin, N., Reitz, T., Wang, Y., Flores, C.M. Epilepsy Res. (2006) [Pubmed]
  14. Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. Maes, T., Barceló, A., Buesa, C. Genomics (2002) [Pubmed]
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