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Gene Review

Vegfb  -  vascular endothelial growth factor B

Rattus norvegicus

Synonyms: VEGF-B, VEGF-related factor, VRF, Vascular endothelial growth factor B, Vrf
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Disease relevance of Vegfb

  • Constitutive expression of VEGF-B in normal endothelium suggests that it may have a role in maintenance of the BBB in steady states, while its induction at both the gene and protein level post-injury indicates that it has an essential role in angiogenesis and the repair processes after brain injury [1].
  • A few studies have indicated that VEGF-A may play a role in the pathogenesis of multiple sclerosis (MS), but the role of VEGF-B has not been studied [2].

High impact information on Vegfb


Other interactions of Vegfb

  • In this study, VEGF-A expression was compared with that of VEGF-B in the rat cortical cold injury model over a period of 6 hours to 6 days post-injury [1].

Analytical, diagnostic and therapeutic context of Vegfb


  1. Differential expression of vascular endothelial growth factor-A (VEGF-A) and VEGF-B after brain injury. Nag, S., Eskandarian, M.R., Davis, J., Eubanks, J.H. J. Neuropathol. Exp. Neurol. (2002) [Pubmed]
  2. Decreased Expression of VEGF-A in Rat Experimental Autoimmune Encephalomyelitis and in Cerebrospinal Fluid Mononuclear Cells from Patients with Multiple Sclerosis. Tham, E., Gielen, A.W., Khademi, M., Martin, C., Piehl, F. Scand. J. Immunol. (2006) [Pubmed]
  3. Cold-induced mRNA expression of angiogenic factors in rat brown adipose tissue. Asano, A., Kimura, K., Saito, M. J. Vet. Med. Sci. (1999) [Pubmed]
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