Disease relevance of Vegfb

• Constitutive expression of VEGF-B in normal endothelium suggests that it may have a role in maintenance of the BBB in steady states, while its induction at both the gene and protein level post-injury indicates that it has an essential role in angiogenesis and the repair processes after brain injury [1].
• A few studies have indicated that VEGF-A may play a role in the pathogenesis of multiple sclerosis (MS), but the role of VEGF-B has not been studied [2].

High impact information on Vegfb

• Lesion vessels showing BBB breakdown to fibronectin showed endothelial VEGF-A protein but not VEGF-B protein [1].
• VEGF-B protein was constitutively expressed in endothelium of all cerebral vessels [1].
• After brain injury, there was increased immunoreactivity for VEGF-B at the lesion site, this protein being present in the endothelium and vascular smooth muscle cells of pial vessels, in inflammatory cells, and later in proliferating endothelial cells, endothelium of neovessels, and astrocytes [1].
• VEGF-B, a related molecule, is highly expressed in the central nervous system and seems to be important in neurological injury [2].
• In the present study, we examined the effect of cold exposure on mRNA expression of other two angiogenic factors, VEGF-B and basic fibroblast growth factor (bFGF), in rats [3].

Other interactions of Vegfb

• In this study, VEGF-A expression was compared with that of VEGF-B in the rat cortical cold injury model over a period of 6 hours to 6 days post-injury [1].

Analytical, diagnostic and therapeutic context of Vegfb

• VEGF-A and VEGF-B mRNA were detected by in situ hybridization and their protein was detected by immunohistochemistry [1].
• Conventional Northern blot analysis revealed abundant mRNA expression of VEGF-B as well as VEGF, but not bFGF, in BAT [3].

References