The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

CCR9  -  chemokine (C-C motif) receptor 9

Homo sapiens

Synonyms: C-C CKR-9, C-C chemokine receptor type 9, CC-CKR-9, CCR-9, CDw199, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of CCR9

 

High impact information on CCR9

 

Biological context of CCR9

 

Anatomical context of CCR9

 

Associations of CCR9 with chemical compounds

 

Other interactions of CCR9

  • The transcription map also includes the CC chemokine receptor 9 gene (CCR9) and the LIM domain containing gene 1 (LIMD1) [18].
  • Importantly, the expression profile of GPR-9-6 correlates with migration to TECK of blood T lymphocytes and thymocytes [8].
  • We isolated cDNAs for a chemokine receptor-related protein having the database designation GPR-9-6 [19].
  • Furthermore, a greater percentage of the breast milk CD8(+) T cells expressed the intestinal homing receptor, CD103, and the mucosal homing receptor CCR9 [20].
 

Analytical, diagnostic and therapeutic context of CCR9

  • This notion was supported by the small number of CCR9+ naive T cells which was present shortly after thymectomy [21].
  • Immunohistochemistry revealed that the leukemic cells in the gut still expressed CCR9 and colocalized with a high expression of the CCR9 ligand, CCL25 [22].
  • RESULTS: The expression of cutaneous leukocyte antigen (CLA) and CC-chemokine receptor 4 (CCR4; associated with skin-homing) as well as the expression of integrin alpha4beta7 and CCR9 (associated with gut-homing) was analyzed on CD4+ memory T cells in CSF from individuals with non-inflammatory neurological diseases using flow cytometry [23].
  • Thus, dissection of signaling components involved in the CCR9-mediated antiapoptosis could be a framework for cell survival mechanisms and may provide options for therapeutic interventions for neurdegenerative diseases or T cell malfunctioning [17].
  • The study of beta-thalassemia was made by PCR-ARMS, the alpha genes by Southern blot, the phenotype of Hb Lepore by enzymatic amplification and the presence of -158 gamma G C-->T mutation by PCR and digestion with the restriction enzyme XmnL [24].

References

  1. CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease. Papadakis, K.A., Prehn, J., Moreno, S.T., Cheng, L., Kouroumalis, E.A., Deem, R., Breaverman, T., Ponath, P.D., Andrew, D.P., Green, P.H., Hodge, M.R., Binder, S.W., Targan, S.R. Gastroenterology (2001) [Pubmed]
  2. Selectively increased expression and functions of chemokine receptor CCR9 on CD4+ T cells from patients with T-cell lineage acute lymphocytic leukemia. Qiuping, Z., Qun, L., Chunsong, H., Xiaolian, Z., Baojun, H., Mingzhen, Y., Chengming, L., Jinshen, H., Qingping, G., Kejian, Z., Zhimin, S., Xuejun, Z., Junyan, L., Jinquan, T. Cancer Res. (2003) [Pubmed]
  3. The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system. Papadakis, K.A., Prehn, J., Nelson, V., Cheng, L., Binder, S.W., Ponath, P.D., Andrew, D.P., Targan, S.R. J. Immunol. (2000) [Pubmed]
  4. The orphan seven-transmembrane receptor apj supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type 1. Choe, H., Farzan, M., Konkel, M., Martin, K., Sun, Y., Marcon, L., Cayabyab, M., Berman, M., Dorf, M.E., Gerard, N., Gerard, C., Sodroski, J. J. Virol. (1998) [Pubmed]
  5. Expression and functional role of CCR9 in prostate cancer cell migration and invasion. Singh, S., Singh, U.P., Stiles, J.K., Grizzle, W.E., Lillard, J.W. Clin. Cancer Res. (2004) [Pubmed]
  6. CD8(+) recent thymic emigrants home to and efficiently repopulate the small intestine epithelium. Staton, T.L., Habtezion, A., Winslow, M.M., Sato, T., Love, P.E., Butcher, E.C. Nat. Immunol. (2006) [Pubmed]
  7. Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. Kunkel, E.J., Campbell, J.J., Haraldsen, G., Pan, J., Boisvert, J., Roberts, A.I., Ebert, E.C., Vierra, M.A., Goodman, S.B., Genovese, M.C., Wardlaw, A.J., Greenberg, H.B., Parker, C.M., Butcher, E.C., Andrew, D.P., Agace, W.W. J. Exp. Med. (2000) [Pubmed]
  8. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. Zabel, B.A., Agace, W.W., Campbell, J.J., Heath, H.M., Parent, D., Roberts, A.I., Ebert, E.C., Kassam, N., Qin, S., Zovko, M., LaRosa, G.J., Yang, L.L., Soler, D., Butcher, E.C., Ponath, P.D., Parker, C.M., Andrew, D.P. J. Exp. Med. (1999) [Pubmed]
  9. CC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profile. Papadakis, K.A., Landers, C., Prehn, J., Kouroumalis, E.A., Moreno, S.T., Gutierrez-Ramos, J.C., Hodge, M.R., Targan, S.R. J. Immunol. (2003) [Pubmed]
  10. Premature expression of chemokine receptor CCR9 impairs T cell development. Uehara, S., Hayes, S.M., Li, L., El-Khoury, D., Canelles, M., Fowlkes, B.J., Love, P.E. J. Immunol. (2006) [Pubmed]
  11. CD18 Is Required for Intestinal T Cell Responses at Multiple Immune Checkpoints. Marski, M., Ye, A.L., Abraham, C. J. Immunol. (2007) [Pubmed]
  12. TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor. Youn, B.S., Kim, C.H., Smith, F.O., Broxmeyer, H.E. Blood (1999) [Pubmed]
  13. Evidence for NK cell subsets based on chemokine receptor expression. Berahovich, R.D., Lai, N.L., Wei, Z., Lanier, L.L., Schall, T.J. J. Immunol. (2006) [Pubmed]
  14. Different Neurotropic Pathogens Elicit Neurotoxic CCR9- or Neurosupportive CXCR3-Expressing Microglia. Li, H., Gang, Z., Yuling, H., Luokun, X., Jie, X., Hao, L., Li, W., Chunsong, H., Junyan, L., Mingshen, J., Youxin, J., Feili, G., Boquan, J., Jinquan, T. J. Immunol. (2006) [Pubmed]
  15. Expression of CCR9 in HTLV-1(+) T cells and ATL cells expressing Tax. Nagakubo, D., Jin, Z., Hieshima, K., Nakayama, T., Shirakawa, A.K., Tanaka, Y., Hasegawa, H., Hayashi, T., Tsukasaki, K., Yamada, Y., Yoshie, O. Int. J. Cancer (2007) [Pubmed]
  16. The greater chemotactic network for lymphocyte trafficking: chemokines and beyond. Kim, C.H. Curr. Opin. Hematol. (2005) [Pubmed]
  17. Role of the CC chemokine receptor 9/TECK interaction in apoptosis. Youn, B.S., Yu, K.Y., Oh, J., Lee, J., Lee, T.H., Broxmeyer, H.E. Apoptosis (2002) [Pubmed]
  18. The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3. Kiss, H., Kedra, D., Kiss, C., Kost-Alimova, M., Yang, Y., Klein, G., Imreh, S., Dumanski, J.P. Genomics (2001) [Pubmed]
  19. CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand. Yu, C.R., Peden, K.W., Zaitseva, M.B., Golding, H., Farber, J.M. J. Immunol. (2000) [Pubmed]
  20. Breast milk-derived antigen-specific CD8+ T cells: an extralymphoid effector memory cell population in humans. Sabbaj, S., Ghosh, M.K., Edwards, B.H., Leeth, R., Decker, W.D., Goepfert, P.A., Aldrovandi, G.M. J. Immunol. (2005) [Pubmed]
  21. Age-related changes in CCR9+ circulating lymphocytes: are CCR9+ naive T cells recent thymic emigrants? Olaussen, R.W., Farstad, I.N., Brandtzaeg, P., Rugtveit, J. Scand. J. Immunol. (2001) [Pubmed]
  22. Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL. Annels, N.E., Willemze, A.J., van der Velden, V.H., Faaij, C.M., van Wering, E., Sie-Go, D.M., Egeler, R.M., van Tol, M.J., Révész, T. Blood (2004) [Pubmed]
  23. Human cerebrospinal fluid contains CD4+ memory T cells expressing gut- or skin-specific trafficking determinants: relevance for immunotherapy. Kivisäkk, P., Tucky, B., Wei, T., Campbell, J.J., Ransohoff, R.M. BMC Immunol. (2006) [Pubmed]
  24. High incidence of the CD8/9 (+G) beta 0-thalassemia mutation in Spain. Villegas, A., Ropero, P., Ataulfo González, F., Martí, E., Anguita, E., de Blas, J.M. Haematologica (1998) [Pubmed]
 
WikiGenes - Universities