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Gene Review:

MIDN - midnolin

Homo sapiens

Synonyms: Midbrain nucleolar protein, Midnolin

Kok, N.F. et al., Tsukahara, M. et al.

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Disease relevance of MIDN

In the LDN group 4 (8%) major intraoperative and 2 (4%) major postoperative complications occurred versus no major complications in the MIDN group [1].

High impact information on MIDN

One-year graft survival was 100% following MIDN and 86% following LDN (P=0.005) [1].
Expression of the midnolin gene is developmentally regulated: it is strongly expressed at the mesencephalon (midbrain) of the embryo in day 12.5 (E12.5) mice [2].

Analytical, diagnostic and therapeutic context of MIDN

MIDN resulted in significantly shorter warm ischemia and operation time (2.5 vs. 6.5 min and 157 vs. 240 min respectively) [1].
Fifty-one donors underwent mini-incision, muscle-splitting open donor nephrectomy (MIDN) and 49 donors underwent LDN [1].

References

Donor nephrectomy: mini-incision muscle-splitting open approach versus laparoscopy. Kok, N.F., Alwayn, I.P., Lind, M.Y., Tran, K.T., Weimar, W., IJzermans, J.N. Transplantation (2006) [Pubmed]
Novel nucleolar protein, midnolin, is expressed in the mesencephalon during mouse development. Tsukahara, M., Suemori, H., Noguchi, S., Ji, Z.S., Tsunoo, H. Gene (2000) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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midn	Danio rerio
LOC721215	Macaca mulatta
Midn	Mus musculus
LOC749952	Pan troglodytes
Midn	Rattus norvegicus
midn	Xenopus (Silurana) tropicalis

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