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Gene Review

BAZ1B  -  bromodomain adjacent to zinc finger domain...

Homo sapiens

Synonyms: Bromodomain adjacent to zinc finger domain protein 1B, Tyrosine-protein kinase BAZ1B, WBSC10, WBSCR10, WBSCR9, ...
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Disease relevance of BAZ1B


High impact information on BAZ1B


Biological context of BAZ1B

  • The WSTF gene consists of 20 exons spanning about 80 kb [6].
  • The WBSCR9 gene encodes a roughly 7-kb transcript with an open reading frame of 1483 amino acids and a predicted protein product size of 170.8 kDa [7].
  • Haploinsufficiency for WBSCR9 gene products may contribute to the complex phenotype of WBS by interacting with tissue-specific regulatory factors during development [7].
  • NM1, WSTF and SNF2h were found to be associated with RNA polymerase I (Pol I) and ribosomal RNA genes (rDNA) [8].
  • Thus, our findings indicate that WINAC associates with chromatin through a physical interaction between the WSTF bromodomain and acetylated histones, that appears to be indispensable for VDR/promoter association for ligand-induced transrepression of 1alpha(OH)ase gene expression [9].

Anatomical context of BAZ1B


Other interactions of BAZ1B


Analytical, diagnostic and therapeutic context of BAZ1B


  1. WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci. Bozhenok, L., Wade, P.A., Varga-Weisz, P. EMBO J. (2002) [Pubmed]
  2. The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. Kitagawa, H., Fujiki, R., Yoshimura, K., Mezaki, Y., Uematsu, Y., Matsui, D., Ogawa, S., Unno, K., Okubo, M., Tokita, A., Nakagawa, T., Ito, T., Ishimi, Y., Nagasawa, H., Matsumoto, T., Yanagisawa, J., Kato, S. Cell (2003) [Pubmed]
  3. ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly. Ito, T., Levenstein, M.E., Fyodorov, D.V., Kutach, A.K., Kobayashi, R., Kadonaga, J.T. Genes Dev. (1999) [Pubmed]
  4. The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci. Poot, R.A., Bozhenok, L., van den Berg, D.L., Steffensen, S., Ferreira, F., Grimaldi, M., Gilbert, N., Ferreira, J., Varga-Weisz, P.D. Nat. Cell Biol. (2004) [Pubmed]
  5. A family of chromatin remodeling factors related to Williams syndrome transcription factor. Bochar, D.A., Savard, J., Wang, W., Lafleur, D.W., Moore, P., Côté, J., Shiekhattar, R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  6. A novel human gene, WSTF, is deleted in Williams syndrome. Lu, X., Meng, X., Morris, C.A., Keating, M.T. Genomics (1998) [Pubmed]
  7. Identification of the WBSCR9 gene, encoding a novel transcriptional regulator, in the Williams-Beuren syndrome deletion at 7q11.23. Peoples, R.J., Cisco, M.J., Kaplan, P., Francke, U. Cytogenet. Cell Genet. (1998) [Pubmed]
  8. The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription. Percipalle, P., Fomproix, N., Cavellán, E., Voit, R., Reimer, G., Krüger, T., Thyberg, J., Scheer, U., Grummt, I., Ostlund Farrants, A.K. EMBO Rep. (2006) [Pubmed]
  9. Ligand-induced transrepressive function of VDR requires a chromatin remodeling complex, WINAC. Kato, S., Fujiki, R., Kim, M.S., Kitagawa, H. J. Steroid Biochem. Mol. Biol. (2007) [Pubmed]
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