Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

SEMA5A - sema domain, seven thrombospondin repeats...

Homo sapiens

Synonyms: SEMAF, Sema F, Semaphorin-5A, Semaphorin-F, semF

Melin, M. et al., Marvin, K.W. et al., Clarimon, J. et al., Simmons, A.D. et al.

Marvin, Keelan, Eykholt, Sato, Mitchell,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SEMA5A

Conflicting results regarding the semaphorin gene (SEMA5A) and the risk for Parkinson disease [1].
Epstein-Barr virus should be considered as a possible source for altered expression, but our consistent results make us suggest SEMA5A as a candidate gene in the etiology of idiopathic autism [2].
Semaphorin-F expression decreased with preterm labor with chorioamnionitis in choriodecidua (P <.05), although the trend was not significant in amnion (P =.1) [3].

High impact information on SEMA5A

Constitutional Downregulation of SEMA5A Expression in Autism [2].

Analytical, diagnostic and therapeutic context of SEMA5A

Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval [4].
Quantitative real-time PCR confirms the downregulation of the gene encoding SEMA5A, a protein involved in axonal guidance [2].

References

Conflicting results regarding the semaphorin gene (SEMA5A) and the risk for Parkinson disease. Clarimon, J., Scholz, S., Fung, H.C., Hardy, J., Eerola, J., Hellstrom, O., Chen, C.M., Wu, Y.R., Tienari, P.J., Singleton, A. Am. J. Hum. Genet. (2006) [Pubmed]
Constitutional Downregulation of SEMA5A Expression in Autism. Melin, M., Carlsson, B., Anckarsater, H., Rastam, M., Betancur, C., Isaksson, A., Gillberg, C., Dahl, N. Neuropsychobiology (2006) [Pubmed]
Expression of angiogenic and neurotrophic factors in the human amnion and choriodecidua. Marvin, K.W., Keelan, J.A., Eykholt, R.L., Sato, T.A., Mitchell, M.D. Am. J. Obstet. Gynecol. (2002) [Pubmed]
Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval. Simmons, A.D., Püschel, A.W., McPherson, J.D., Overhauser, J., Lovett, M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

SEMA5A	Bos taurus
SEMA5A	Canis lupus familiaris
sema5a	Danio rerio
SEMA5A	Gallus gallus
SEMA5A	Macaca mulatta
Sema5a	Mus musculus
SEMA5A	Pan troglodytes
Sema5a	Rattus norvegicus

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.