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MeSH Review

Obstetric Labor, Premature

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Disease relevance of Obstetric Labor, Premature


Psychiatry related information on Obstetric Labor, Premature

  • Thus, selective COX-2 inhibitors may demonstrate new important therapeutic benefits as anticancer agents, as well as in preventing premature labor and perhaps even retarding the progression of Alzheimer's disease [6].
  • Beta-receptor agonist (terbutalin or isoxsuprin) administration to pregnant women either because of premature labor (therapy group; T; n = 8) or as prophylactic treatment (prophylaxis group; p; n = 8) resulted in a marked drop in serum potassium (p less than 0.001) during the first two hours of infusion in all patients [7].
  • Several studies have implicated CRF in the etiology of anxiety, depression, substance abuse, stress-related gastrointestinal disorders and preterm labor, and intensive research into the design of safe and effective CRF antagonists is currently being pursued in several laboratories [8].

High impact information on Obstetric Labor, Premature


Chemical compound and disease context of Obstetric Labor, Premature

  • Terbutaline, as currently used to prevent premature labor, is a potent inotropic and chronotropic agent [14].
  • It may result from intrauterine infection, which mediates premature labor by stimulating the production of inflammatory lipid mediators such as prostaglandin F2alpha (PGF2alpha) [15].
  • The patient was initially treated with chloroquine; however, she developed bilateral pulmonary infiltrates and premature labor, and her condition appeared to clinically deteriorate [16].
  • Inflammatory cytokines such as interleukin-1 (IL-1) have been implicated as paracrine mediators of decidual prostaglandin (PG) production during preterm labor [17].
  • To study the effect of increased circulating level of corticosteroids on the serum concentration of progestins, 74 women with premature labor with or without premature rupture of membranes were treated with either placebo or 4 im injections of dexamethasone phosphate (5 mg each) at 12-h intervals [18].

Biological context of Obstetric Labor, Premature


Anatomical context of Obstetric Labor, Premature


Gene context of Obstetric Labor, Premature

  • Therefore, COX-1-selective inhibitors may provide effective treatment to delay preterm labor with fewer adverse effects on fetal or neonatal health than nonselective or COX-2-selective inhibitors [28].
  • In contrast, the inhibition of COX-1 during pregnancy lacked these prenatal and postnatal adverse effects on the DA and effectively delayed the initiation of full-term labor and LPS-induced preterm labor [28].
  • IL-1beta plays a key role in infection-induced preterm labor and increases prostaglandin H synthase 2 (PGHS-2) and IL-8 expression [29].
  • As such, it has been suggested that IL-10 could have therapeutic potential, including the treatment of preterm labor [30].
  • Our data support the concept that a complex cytokine network between maternal and fetal gestational tissues exists, and that activation of inflammatory cytokine production in these tissues, including IL-8, likely contributes to the pathophysiology of infection-induced preterm labor [31].

Analytical, diagnostic and therapeutic context of Obstetric Labor, Premature


  1. Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. Carey, J.C., Klebanoff, M.A., Hauth, J.C., Hillier, S.L., Thom, E.A., Ernest, J.M., Heine, R.P., Nugent, R.P., Fischer, M.L., Leveno, K.J., Wapner, R., Varner, M. N. Engl. J. Med. (2000) [Pubmed]
  2. Myocardial infarction during nifedipine therapy for preterm labor. Oei, S.G., Oei, S.K., Brölmann, H.A. N. Engl. J. Med. (1999) [Pubmed]
  3. Angina pectoris associated with use of terbutaline for premature labor. Tye, K.H., Desser, K.B., Benchimol, A. JAMA (1980) [Pubmed]
  4. Ritodrine- and terbutaline-induced hypokalemia in preterm labor: mechanisms and consequences. Braden, G.L., von Oeyen, P.T., Germain, M.J., Watson, D.J., Haag, B.L. Kidney Int. (1997) [Pubmed]
  5. Experimental gestational pyelonephritis induces preterm births and low birth weights in C3H/HeJ mice. Kaul, A.K., Khan, S., Martens, M.G., Crosson, J.T., Lupo, V.R., Kaul, R. Infect. Immun. (1999) [Pubmed]
  6. Anti-inflammatory drugs and their mechanism of action. Vane, J.R., Botting, R.M. Inflamm. Res. (1998) [Pubmed]
  7. Changes in maternal serum aldosterone, potassium and prolactin levels during beta-receptor agonist treatment in third trimester pregnancies. Bremme, K., Eneroth, P., Hagenfeld, L., Hellgren, M. Horm. Metab. Res. (1982) [Pubmed]
  8. Corticotropin-releasing factor antagonists: recent advances and exciting prospects for the treatment of human diseases. Gilligan, P.J., Li, Y.W. Current opinion in drug discovery & development. (2004) [Pubmed]
  9. Neonatal complications after the administration of indomethacin for preterm labor. Norton, M.E., Merrill, J., Cooper, B.A., Kuller, J.A., Clyman, R.I. N. Engl. J. Med. (1993) [Pubmed]
  10. Treatment of preterm labor with the beta-adrenergic agonist ritodrine. Caritis, S.N. N. Engl. J. Med. (1992) [Pubmed]
  11. Fetal fibronectin and preterm labor. Feinberg, R.F., Kliman, H.J. N. Engl. J. Med. (1992) [Pubmed]
  12. Indomethacin in the treatment of premature labor. Effects on the fetal ductus arteriosus. Moise, K.J., Huhta, J.C., Sharif, D.S., Ou, C.N., Kirshon, B., Wasserstrum, N., Cano, L. N. Engl. J. Med. (1988) [Pubmed]
  13. Efficacy of 17alpha-hydroxyprogesterone caproate in the prevention of premature labor. Johnson, J.W., Austin, K.L., Jones, G.S., Davis, G.H., King, T.M. N. Engl. J. Med. (1975) [Pubmed]
  14. Terbutaline and maternal cardiac function. Wagner, J.M., Morton, M.J., Johnson, K.A., O'Grady, J.P., Speroff, L. JAMA (1981) [Pubmed]
  15. Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators. Mandal, A.K., Ray, R., Zhang, Z., Chowdhury, B., Pattabiraman, N., Mukherjee, A.B. J. Biol. Chem. (2005) [Pubmed]
  16. Treatment of severe falciparum malaria during pregnancy with quinidine and exchange transfusion. Wong, R.D., Murthy, A.R., Mathisen, G.E., Glover, N., Thornton, P.J. Am. J. Med. (1992) [Pubmed]
  17. Decidual histamine release and amplification of prostaglandin F2 alpha production by histamine in interleukin-1 beta-primed decidual cells: potential interactive role for inflammatory mediators in uterine function at term. Schrey, M.P., Hare, A.L., Ilson, S.L., Walters, M.P. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  18. Changes in the concentration of 17 alpha,20 alpha-dihydroxypregn-4-en-3-one during pregnancy, labor, and delivery and the effect of dexamethasone treatment during the third trimester of pregnancy. Mahajan, D.K., Anderson, G., Poole, W.K., Billiar, R.B., Little, B. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  19. Disturbed development of the preimplantation embryo in the insulin-dependent diabetic BB/E rat. Lea, R.G., McCracken, J.E., McIntyre, S.S., Smith, W., Baird, J.D. Diabetes (1996) [Pubmed]
  20. Arg16 homozygosity of the beta2-adrenergic receptor improves the outcome after beta2-agonist tocolysis for preterm labor. Landau, R., Morales, M.A., Antonarakis, S.E., Blouin, J.L., Smiley, R.M. Clin. Pharmacol. Ther. (2005) [Pubmed]
  21. Maternal corticotropin-releasing hormone is increased with impending preterm birth. Korebrits, C., Ramirez, M.M., Watson, L., Brinkman, E., Bocking, A.D., Challis, J.R. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  22. Corticotropin-releasing hormone and its receptor distribution in fetal membranes and placenta of the rhesus monkey in late gestation and labor. Wu, W.X., Unno, S., Giussani, D.A., Mecenas, C.A., McDonald, T.J., Nathanielsz, P.W. Endocrinology (1995) [Pubmed]
  23. Cachectin/tumor necrosis factor-alpha formation in human decidua. Potential role of cytokines in infection-induced preterm labor. Casey, M.L., Cox, S.M., Beutler, B., Milewich, L., MacDonald, P.C. J. Clin. Invest. (1989) [Pubmed]
  24. Expression and localization of prostaglandin E synthase isoforms in human fetal membranes in term and preterm labor. Meadows, J.W., Eis, A.L., Brockman, D.E., Myatt, L. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  25. Prostaglandin endoperoxide H synthase (PGHS) activity and PGHS-1 and -2 messenger ribonucleic acid abundance in human chorion throughout gestation and with preterm labor. Mijovic, J.E., Zakar, T., Nairn, T.K., Olson, D.M. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  26. High fetal urocortin levels at term and preterm labor. Florio, P., Torricelli, M., Galleri, L., De Falco, G., Leucci, E., Calonaci, G., Picciolini, E., Ambrosini, G., Linton, E.A., Petraglia, F. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  27. Complex interactions between sex steroids and cytokines in the human pregnant myometrium: evidence for an autocrine signaling system at term. Hatthachote, P., Gillespie, J.I. Endocrinology (1999) [Pubmed]
  28. Cyclooxygenase-1-selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus. Loftin, C.D., Trivedi, D.B., Langenbach, R. J. Clin. Invest. (2002) [Pubmed]
  29. The mitogen-activated protein kinase dependent expression of prostaglandin H synthase-2 and interleukin-8 messenger ribonucleic acid by myometrial cells: the differential effect of stretch and interleukin-1{beta}. Sooranna, S.R., Engineer, N., Loudon, J.A., Terzidou, V., Bennett, P.R., Johnson, M.R. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  30. Paradoxical proinflammatory actions of interleukin-10 in human amnion: potential roles in term and preterm labour. Mitchell, M.D., Simpson, K.L., Keelan, J.A. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  31. Inflammatory mediators regulate interleukin-8 production by cultured gestational tissues: evidence for a cytokine network at the chorio-decidual interface. Dudley, D.J., Trautman, M.S., Mitchell, M.D. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  32. Amniotic fluid interleukin 6 in preterm labor. Association with infection. Romero, R., Avila, C., Santhanam, U., Sehgal, P.B. J. Clin. Invest. (1990) [Pubmed]
  33. ARDS associated with the use of sympathomimetics and glucocorticoids for the treatment of premature labor. Bowen, R.E., Dedhia, H.V., Beatty, J., Schiebel, F., Koss, W., Granados, J. Crit. Care Med. (1983) [Pubmed]
  34. Increased expression of the rat myometrial oxytocin receptor messenger ribonucleic acid during labor requires both mechanical and hormonal signals. Ou, C.W., Chen, Z.Q., Qi, S., Lye, S.J. Biol. Reprod. (1998) [Pubmed]
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