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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CLDN8  -  claudin 8

Homo sapiens

Synonyms: Claudin-8, UNQ779/PRO1573
 
 
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Disease relevance of CLDN8

 

High impact information on CLDN8

  • We show that mRNAs of claudins 1, 3, 4, and 7 are all expressed in different human carcinoma cell lines, while claudin 8 was selectively expressed in breast and pancreas cancer lines [2].
  • We also obtained time course, concentration-response, cyclohexamide sensitivity, and PR-specificity data for two progestin-regulated genes, ATP1A1 and CLDN8 [3].
  • The decrease of C21orf2 may represent mitochondrial dysfunction that has been reported repeatedly and also data on CAR and claudin-8 are not supporting the gene-dosage hypothesis at the protein level [4].
  • Claudin-8 is a tight junction protein that acts as a paracellular cation barrier in the distal nephron [1].
 

Analytical, diagnostic and therapeutic context of CLDN8

References

  1. Genetic heterogeneity in autosomal dominant pseudohypoaldosteronism type I: exclusion of claudin-8 as a candidate gene. Huey, C.L., Riepe, F.G., Sippell, W.G., Yu, A.S. American journal of nephrology. (2004) [Pubmed]
  2. Epithelial tight junction proteins as potential antibody targets for pancarcinoma therapy. Offner, S., Hekele, A., Teichmann, U., Weinberger, S., Gross, S., Kufer, P., Itin, C., Baeuerle, P.A., Kohleisen, B. Cancer Immunol. Immunother. (2005) [Pubmed]
  3. Regulation of gene expression by PRA-910, a novel progesterone receptor modulator, in T47D cells. Bray, J.D., Zhang, Z., Winneker, R.C., Lyttle, C.R. Steroids (2003) [Pubmed]
  4. Reduction of chromatin assembly factor 1 p60 and C21orf2 protein, encoded on chromosome 21, in Down syndrome brain. Shim, K.S., Bergelson, J.M., Furuse, M., Ovod, V., Krude, T., Lubec, G. J. Neural Transm. Suppl. (2003) [Pubmed]
  5. Claudin-8 interacts with multi-PDZ domain protein 1 (MUPP1) and reduces paracellular conductance in epithelial cells. Jeansonne, B., Lu, Q., Goodenough, D.A., Chen, Y.H. Cell. Mol. Biol. (Noisy-le-grand) (2003) [Pubmed]
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