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Gene Review

ATP1A1  -  ATPase, Na+/K+ transporting, alpha 1...

Homo sapiens

Synonyms: Na(+)/K(+) ATPase alpha-1 subunit, Sodium pump subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-1
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Disease relevance of ATP1A1


High impact information on ATP1A1

  • Na,K-ATPase alpha 1 subunit gene (ATP1A1) is one of the housekeeping genes involved in homeostasis of Na+ and K+ in all animal cells [5].
  • Sodium pump activity and Na+/H+ exchange were measured in erythrocytes from 49 cancer patients and 51 healthy subjects [6].
  • IDDM patients bearing the ATP1 A1 variant detected by Bgl II RFLP are much more frequently affected by neuropathy (relative risk 6.5, with 95% CI 3.3-13) [7].
  • We have determined the sequence of the 5'-flanking region and first three exons of the human Na,K-ATPase alpha 1 gene, ATP1A1 [8].
  • The results obtained have allowed us to assign the loci for the ubiquitously expressed alpha-chain (ATP1A1) to human chromosome 1, region 1p21----cen, and for the alpha 2 isoform that predominates in neural and muscle tissues (ATP1A2) to chromosome 1, region cen----q32 [9].

Biological context of ATP1A1


Anatomical context of ATP1A1


Associations of ATP1A1 with chemical compounds


Other interactions of ATP1A1


Analytical, diagnostic and therapeutic context of ATP1A1


  1. Non-association of the thiazide-sensitive Na,Cl-cotransporter gene with polygenic hypertension in both rats and humans. Song, Y., Herrera, V.L., Filigheddu, F., Troffa, C., Lopez, L.V., Glorioso, N., Ruiz-Opazo, N. J. Hypertens. (2001) [Pubmed]
  2. Genetic and environmental regulation of Na/K adenosine triphosphatase activity in diabetic patients. Jannot, M.F., Raccah, D., De La Tour, D.D., Coste, T., Vague, P. Metab. Clin. Exp. (2002) [Pubmed]
  3. Sodium pump numbers and cation transport of lymphocytes in pregnancy-induced hypertension. Ang, L.M., Taylor, E.A., Oh, V.M. J. Hypertens. (1990) [Pubmed]
  4. Alterations in uterine sodium pump abundance may contribute to the onset and progression of term and preterm labor in mice. Vance, C.J., Esplin, M.S., Hamblin, S., Graves, S.W. Am. J. Obstet. Gynecol. (2006) [Pubmed]
  5. Housekeeping Na,K-ATPase alpha 1 subunit gene promoter is composed of multiple cis elements to which common and cell type-specific factors bind. Suzuki-Yagawa, Y., Kawakami, K., Nagano, K. Mol. Cell. Biol. (1992) [Pubmed]
  6. Impairment of sodium pump and Na+/H+ antiport in erythrocytes isolated from cancer patients. Borg, A.L., Gallice, P.M., Kovacic, H.N., Nicoara, A.E., Favre, R.G., Crevat, A.D. Cancer Res. (1996) [Pubmed]
  7. Association of diabetic neuropathy with Na/K ATPase gene polymorphism. Vague, P., Dufayet, D., Coste, T., Moriscot, C., Jannot, M.F., Raccah, D. Diabetologia (1997) [Pubmed]
  8. The human Na, K-ATPase alpha 1 gene: characterization of the 5'-flanking region and identification of a restriction fragment length polymorphism. Shull, M.M., Pugh, D.G., Lingrel, J.B. Genomics (1990) [Pubmed]
  9. Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes. Yang-Feng, T.L., Schneider, J.W., Lindgren, V., Shull, M.M., Benz, E.J., Lingrel, J.B., Francke, U. Genomics (1988) [Pubmed]
  10. Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension. Glorioso, N., Filigheddu, F., Troffa, C., Soro, A., Parpaglia, P.P., Tsikoudakis, A., Myers, R.H., Herrera, V.L., Ruiz-Opazo, N. Hypertension (2001) [Pubmed]
  11. Sodium pump reduction correlates with aortic clamp time in pediatric heart surgery. Pavlovic, M., Schaller, A., Ammann, R.A., Pfammatter, J.P., Berdat, P., Carrel, T., Gallati, S. Exp. Biol. Med. (Maywood) (2006) [Pubmed]
  12. Erythrocyte sodium fluxes, ouabain binding sites, and Na+,K(+)-ATPase activity in hyperthyroidism. Arumanayagam, M., MacDonald, D., Cockram, C.S., Swaminathan, R. Metab. Clin. Exp. (1990) [Pubmed]
  13. C-peptide, Na+,K(+)-ATPase, and diabetes. Vague, P., Coste, T.C., Jannot, M.F., Raccah, D., Tsimaratos, M. Exp. Diabesity Res. (2004) [Pubmed]
  14. Sodium pump molecular activity and membrane lipid composition in two disparate ectotherms, and comparison with endotherms. Turner, N., Hulbert, A.J., Else, P.L. J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. (2005) [Pubmed]
  15. Sodium pump stimulation by oxytocin and cyclic AMP in the isolated epithelium of the frog skin. Aceves, J. Pflugers Arch. (1977) [Pubmed]
  16. P-glycoprotein expression in human major and minor salivary glands. Uematsu, T., Yamaoka, M., Matsuura, T., Doto, R., Hotomi, H., Yamada, A., Hasumi-Nakayama, Y., Kayamoto, D. Arch. Oral Biol. (2001) [Pubmed]
  17. Familial aggregation of red blood cell cation transport systems in Japanese families. Kagamimori, S., Naruse, Y., Takata, M., Fujita, T., Watanabe, M. Am. J. Epidemiol. (1985) [Pubmed]
  18. Sodium pump activity and contractile effect of ouabain in human placental veins. Marín, J., Fernández-Alfonso, M.S., Sánchez-Ferrer, C.F. Eur. J. Pharmacol. (1991) [Pubmed]
  19. Sodium pump activation by 5-hydroxytryptamine in human placental veins. Fernández-Alfonso, M.S., Sánchez-Ferrer, C.F., Marín, J. Eur. J. Pharmacol. (1992) [Pubmed]
  20. Sodium pump and steroid hormone receptor. Na(+)/K(+)-ATPase. Schoner, W. Eur. J. Biochem. (2002) [Pubmed]
  21. Membrane incorporation of non-esterified fatty acids and effects on the sodium pump of human erythrocytes. Dwight, J.F., Mendes Ribeiro, A.C., Hendry, B.M. Clin. Sci. (1992) [Pubmed]
  22. Sodium pump and calcium channel modulation of Mg-deficiency cardiomyopathy. Ahmad, A., Bloom, S. The American journal of cardiovascular pathology. (1989) [Pubmed]
  23. Sodium pump isoforms in xenotransplantation: importance of biochemical compatibility. Rose, A.M., Qazzaz, H.M., Zolotarjova, N., Mellett, B.J., Martin, A.W., Valdes, R. Clin. Chem. (2000) [Pubmed]
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