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Gene Review

dsrA  -  miscRNA

Escherichia coli O157:H7 str. Sakai

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Disease relevance of dsrA

  • The coding region for a Leuconostoc mesenteroides NRRL B-1299 dextransucrase gene (dsrA) was isolated and sequenced [1].
  • E. coli K-12 strains, as well as pathogenic E. coli O157:H7, exhibited compromised acid resistance in dsrA mutants [2].
  • The dsrA gene encoding the molybdoenzyme dimethyl sulfoxide reductase was isolated by screening phagemid libraries containing restriction fragments of Rhodobacter sphaeroides f. sp. denitrificans genomic DNA with a pool of degenerate oligonucleotides [3].

High impact information on dsrA

  • Conversely, overproduction of DsrA from a plasmid rendered the acid-sensitive dsrA mutant extremely acid resistant [2].
  • The nucleotide sequence of the dsrA gene was determined and found to consist of an open reading frame (ORF) of 4870 base pairs (bp) coding for a 1290-aa protein with an M(r) of 145590 [1].
  • In addition to the dsrA and dsrB genes, this operon contains a gene (dsrD) encoding a protein of only 78 amino acids [4].

Analytical, diagnostic and therapeutic context of dsrA

  • This PCR product was used as an hybridization probe to isolate a 1.8-kb fragment identified as the central region of dsrA [1].


  1. Cloning and sequencing of a gene coding for a novel dextransucrase from Leuconostoc mesenteroides NRRL B-1299 synthesizing only alpha (1-6) and alpha (1-3) linkages. Monchois, V., Willemot, R.M., Remaud-Simeon, M., Croux, C., Monsan, P. Gene (1996) [Pubmed]
  2. The small noncoding DsrA RNA is an acid resistance regulator in Escherichia coli. Lease, R.A., Smith, D., McDonough, K., Belfort, M. J. Bacteriol. (2004) [Pubmed]
  3. Molecular cloning of dimethyl sulfoxide reductase from Rhodobacter sphaeroides. Hilton, J.C., Rajagopalan, K.V. Biochim. Biophys. Acta (1996) [Pubmed]
  4. Overexpression, purification and immunodetection of DsrD from Desulfovibrio vulgaris Hildenborough. Hittel, D.S., Voordouw, G. Antonie Van Leeuwenhoek (2000) [Pubmed]
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