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Gene Review

rnhB  -  ribonuclease HII

Escherichia coli O157:H7 str. Sakai

 
 
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Disease relevance of rnhB

 

High impact information on rnhB

  • Two RNases H of mammalian tissues have been described: RNase HI, the activity of which was found to rise during DNA replication, and RNase HII, which may be involved in transcription [5].
  • Interestingly, the deduced amino acid sequence of this subunit of human RNase HI displays significant homology to RNase HII from E. coli, an enzyme of unknown function and previously judged as a minor activity [5].
  • Statistical models, hidden Markov models (HMMs), were created for the RNase HII, III, II and PH and D families as well as a double-stranded RNA binding domain present in RNase III [6].
  • The midpoint of the urea denaturation curve and optimum temperature of SIB1 RNase HII were lower than those of E. coli RNase HII by approximately 0.2 m and approximately 5 degrees C, respectively [4].

References

 
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