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Gene Review

ECs3837  -  adenine DNA glycosylase

Escherichia coli O157:H7 str. Sakai

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Disease relevance of ECs3837


High impact information on ECs3837


Chemical compound and disease context of ECs3837

  • Like the MutY(Ec) protein, purified recombinant MutY(Dr) expressed in E. coli has adenine glycosylase activity with A/G, A/C, and A/GO mismatches and weak guanine glycosylase activity with a G/GO mismatch [7].

Biological context of ECs3837


Associations of ECs3837 with chemical compounds


  1. Flipping duplex DNA inside out: a double base-flipping reaction mechanism by Escherichia coli MutY adenine glycosylase. Bernards, A.S., Miller, J.K., Bao, K.K., Wong, I. J. Biol. Chem. (2002) [Pubmed]
  2. Insight into the functional consequences of hMYH variants associated with colorectal cancer: distinct differences in the adenine glycosylase activity and the response to AP endonucleases of Y150C and G365D murine MYH. Pope, M.A., Chmiel, N.H., David, S.S. DNA Repair (Amst.) (2005) [Pubmed]
  3. A dimeric mechanism for contextual target recognition by MutY glycosylase. Wong, I., Bernards, A.S., Miller, J.K., Wirz, J.A. J. Biol. Chem. (2003) [Pubmed]
  4. The active site of the Escherichia coli MutY DNA adenine glycosylase. Wright, P.M., Yu, J., Cillo, J., Lu, A.L. J. Biol. Chem. (1999) [Pubmed]
  5. Identification of the structural and functional domains of MutY, an Escherichia coli DNA mismatch repair enzyme. Manuel, R.C., Czerwinski, E.W., Lloyd, R.S. J. Biol. Chem. (1996) [Pubmed]
  6. Insight into the roles of tyrosine 82 and glycine 253 in the Escherichia coli adenine glycosylase MutY. Livingston, A.L., Kundu, S., Henderson Pozzi, M., Anderson, D.W., David, S.S. Biochemistry (2005) [Pubmed]
  7. Molecular cloning and functional analysis of the MutY homolog of Deinococcus radiodurans. Li, X., Lu, A.L. J. Bacteriol. (2001) [Pubmed]
  8. Noncysteinyl coordination to the [4Fe-4S]2+ cluster of the DNA repair adenine glycosylase MutY introduced via site-directed mutagenesis. Structural characterization of an unusual histidinyl-coordinated cluster. Messick, T.E., Chmiel, N.H., Golinelli, M.P., Langer, M.R., Joshua-Tor, L., David, S.S. Biochemistry (2002) [Pubmed]
  9. A single engineered point mutation in the adenine glycosylase MutY confers bifunctional glycosylase/AP lyase activity. Williams, S.D., David, S.S. Biochemistry (2000) [Pubmed]
  10. Role of a MutY DNA glycosylase in combating oxidative DNA damage in Helicobacter pylori. Eutsey, R., Wang, G., Maier, R.J. DNA Repair (Amst.) (2007) [Pubmed]
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