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Gene Review

lef-1  -  ORF11

Epiphyas postvittana nucleopolyhedrovirus

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Disease relevance of lef-1


High impact information on lef-1

  • Upon ultracentrifugation in glycerol gradients, LEF-1 was found to have a sedimentation coefficient of 3S that is consistent with its being present as a monomer [1].
  • Mutation of an invariant aspartic acid in a putative primase domain caused LEF-1 activity to be abolished [1].
  • The LEF-1 primase was absolutely dependent on divalent cations (Mg(2+)), and optimal activity was supported by 10 mM MgCl(2) [1].
  • The LEF-1 primase products were also directly characterized by electrophoresis in 20% polyacrylamide-8 M urea gels and agarose gels [1].


  1. Baculovirus replication factor LEF-1 is a DNA primase. Mikhailov, V.S., Rohrmann, G.F. J. Virol. (2002) [Pubmed]
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