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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HS6ST1  -  heparan sulfate 6-O-sulfotransferase 1

Homo sapiens

Synonyms: HH15, HS6ST, HS6ST-1, Heparan-sulfate 6-O-sulfotransferase 1
 
 
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High impact information on HS6ST1

  • When the cDNA for the entire coding sequence of the protein was inserted into a eukaryotic expression vector and transfected into COS-7 cells, the HS6ST activity increased 7-fold over the control [1].
  • Heparan-sulfate 6-sulfotransferase (HS6ST) catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to position 6 of the N-sulfoglucosamine residue of heparan sulfate [1].
  • In the present study, we have characterized HS6ST-2 and HS6ST-1 human isologues, including their chromosomal localizations [2].
  • Heparan sulphate 6- O -sulphotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in HS [2].
  • Our results suggest that two of these genes, HS6ST and E2F, and LINE 1 elements may be involved in ovarian development [3].
 

Analytical, diagnostic and therapeutic context of HS6ST1

References

  1. Molecular characterization and expression of heparan-sulfate 6-sulfotransferase. Complete cDNA cloning in human and partial cloning in Chinese hamster ovary cells. Habuchi, H., Kobayashi, M., Kimata, K. J. Biol. Chem. (1998) [Pubmed]
  2. Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties. Habuchi, H., Miyake, G., Nogami, K., Kuroiwa, A., Matsuda, Y., Kusche-Gullberg, M., Habuchi, O., Tanaka, M., Kimata, K. Biochem. J. (2003) [Pubmed]
  3. Mapping of the POF1 locus and identification of putative genes for premature ovarian failure. Davison, R.M., Fox, M., Conway, G.S. Mol. Hum. Reprod. (2000) [Pubmed]
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