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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Hs6st1  -  heparan sulfate 6-O-sulfotransferase 1

Mus musculus

Synonyms: 6OST1, HS6ST-1, Heparan-sulfate 6-O-sulfotransferase 1, mHS6ST-1
 
 
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High impact information on Hs6st1

  • Oligosaccharide library-based assessment of heparan sulfate 6-O-sulfotransferase substrate specificity [1].
  • We confirmed that, when the protein encoded by the cDNA was expressed in COS-7 cells, it showed HS6ST activity [2].
  • The cDNAs have been obtained from mouse brain cDNA library by cross-hybridization with human HS6ST cDNA [3].
  • These findings suggest that the stem region of HS6ST plays an important role in normal functioning, including the transit of HS6ST to the Golgi apparatus and maintaining the active conformation essential for enzyme activity [4].
  • Differential expression of heparan sulfate 6-O-sulfotransferase isoforms in the mouse embryo suggests distinctive roles during organogenesis [5].
 

Biological context of Hs6st1

  • We identified different axon navigation phenotypes in two heparan sulfate sulfotransferase (Hst) mutant embryos, Hs2st-/- and Hs6st1-/-, each lacking an enzyme that catalyzes a particular HSPG modification [6].
 

Anatomical context of Hs6st1

  • We suggest that (1) Hs2st and Hs6st1 are each deployed to generate distinct patterns of heparan sulfation on RGCs and at the optic chiasm and (2) this differential sulfation directs retinal axons through the chiasm, at least in part by modulating the response of the navigating growth cone to Slit proteins [6].
  • Overexpression of each isoform in COS-7 cells resulted in about 10-fold increase of HS6ST activity [3].

References

  1. Oligosaccharide library-based assessment of heparan sulfate 6-O-sulfotransferase substrate specificity. Jemth, P., Smeds, E., Do, A.T., Habuchi, H., Kimata, K., Lindahl, U., Kusche-Gullberg, M. J. Biol. Chem. (2003) [Pubmed]
  2. Drosophila heparan sulfate 6-O-sulfotransferase (dHS6ST) gene. Structure, expression, and function in the formation of the tracheal system. Kamimura, K., Fujise, M., Villa, F., Izumi, S., Habuchi, H., Kimata, K., Nakato, H. J. Biol. Chem. (2001) [Pubmed]
  3. The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. Habuchi, H., Tanaka, M., Habuchi, O., Yoshida, K., Suzuki, H., Ban, K., Kimata, K. J. Biol. Chem. (2000) [Pubmed]
  4. Stem domains of heparan sulfate 6-O-sulfotransferase are required for Golgi localization, oligomer formation and enzyme activity. Nagai, N., Habuchi, H., Esko, J.D., Kimata, K. J. Cell. Sci. (2004) [Pubmed]
  5. Differential expression of heparan sulfate 6-O-sulfotransferase isoforms in the mouse embryo suggests distinctive roles during organogenesis. Sedita, J., Izvolsky, K., Cardoso, W.V. Dev. Dyn. (2004) [Pubmed]
  6. Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm. Pratt, T., Conway, C.D., Tian, N.M., Price, D.J., Mason, J.O. J. Neurosci. (2006) [Pubmed]
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