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Chemical Compound Review

phosphoadenosine phosphosulfate     6-amino-9-[(2R,3R,4S,5R)-3- hydroxy-5...

Synonyms: PAPS, CHEBI:17980, HMDB01134, AC1Q6XLW, LS-15195, ...
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Disease relevance of phosphoadenosine phosphosulfate


High impact information on phosphoadenosine phosphosulfate


Chemical compound and disease context of phosphoadenosine phosphosulfate


Biological context of phosphoadenosine phosphosulfate


Anatomical context of phosphoadenosine phosphosulfate


Associations of phosphoadenosine phosphosulfate with other chemical compounds


Gene context of phosphoadenosine phosphosulfate


Analytical, diagnostic and therapeutic context of phosphoadenosine phosphosulfate


  1. Three members of a novel small gene-family from Arabidopsis thaliana able to complement functionally an Escherichia coli mutant defective in PAPS reductase activity encode proteins with a thioredoxin-like domain and "APS reductase" activity. Gutierrez-Marcos, J.F., Roberts, M.A., Campbell, E.I., Wray, J.L. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Substance-dependent sex differences in the activation of benzylic alcohols to mutagens by hepatic sulfotransferases of the rat. Glatt, H., Pauly, K., Frank, H., Seidel, A., Oesch, F., Harvey, R.G., Werle-Schneider, G. Carcinogenesis (1994) [Pubmed]
  3. Rat chondrosarcoma ATP sulfurylase and adenosine 5'-phosphosulfate kinase reside on a single bifunctional protein. Lyle, S., Stanczak, J., Ng, K., Schwartz, N.B. Biochemistry (1994) [Pubmed]
  4. Identification of a third sulfate activation system in Sinorhizobium sp. strain BR816: the CysDN sulfate activation complex. Snoeck, C., Verreth, C., Hernández-Lucas, I., Martínez-Romero, E., Vanderleyden, J. Appl. Environ. Microbiol. (2003) [Pubmed]
  5. Adenosine-5'-phosphosulfate (APS) as sulfate donor for assimilatory sulfate reduction in Rhodospirillum rubrum. Schmidt, A. Arch. Microbiol. (1977) [Pubmed]
  6. 3-Hydroxyxanthine: transplacental effects and ontogeny of related sulfate metabolism in rats and mice. Anderson, L.M., McDonald, J.J., Budinger, J.M., Mountain, I.M., Brown, G.B. J. Natl. Cancer Inst. (1978) [Pubmed]
  7. Loss of chondroitin 6-O-sulfotransferase-1 function results in severe human chondrodysplasia with progressive spinal involvement. Thiele, H., Sakano, M., Kitagawa, H., Sugahara, K., Rajab, A., Höhne, W., Ritter, H., Leschik, G., Nürnberg, P., Mundlos, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  8. Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). Sonoda, J., Xie, W., Rosenfeld, J.M., Barwick, J.L., Guzelian, P.S., Evans, R.M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. A member of a family of sulfate-activating enzymes causes murine brachymorphism. Kurima, K., Warman, M.L., Krishnan, S., Domowicz, M., Krueger, R.C., Deyrup, A., Schwartz, N.B. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  10. Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. Ouyang, Y., Lane, W.S., Moore, K.L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  11. Cloning of the 3'-phosphoadenylyl sulfate reductase and sulfite reductase genes from Escherichia coli K-12. Li, C., Peck, H.D., Przybyla, A.E. Gene (1987) [Pubmed]
  12. Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. Honda, S., Sasaki, Y., Ohsawa, K., Imai, Y., Nakamura, Y., Inoue, K., Kohsaka, S. J. Neurosci. (2001) [Pubmed]
  13. The 3'-terminal exon of the family of steroid and phenol sulfotransferase genes is spliced at the N-terminal glycine of the universally conserved GXXGXXK motif that forms the sulfonate donor binding site. Chiba, H., Komatsu, K., Lee, Y.C., Tomizuka, T., Strott, C.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  14. Activation of a beta-hydroxyalkylnitrosamine to alkylating agents: evidence for the involvement of a sulfotransferase. Kroeger-Koepke, M.B., Koepke, S.R., Hernandez, L., Michejda, C.J. Cancer Res. (1992) [Pubmed]
  15. Novel flavonol 3-sulfotransferase. Purification, kinetic properties, and partial amino acid sequence. Varin, L., Ibrahim, R.K. J. Biol. Chem. (1992) [Pubmed]
  16. Purification, cloning, and bacterial expression of retinol dehydratase from Spodoptera frugiperda. Grün, F., Noy, N., Hämmerling, U., Buck, J. J. Biol. Chem. (1996) [Pubmed]
  17. Identification of amino acid residues critical for catalysis and cosubstrate binding in the flavonol 3-sulfotransferase. Marsolais, F., Varin, L. J. Biol. Chem. (1995) [Pubmed]
  18. Hepatic metabolism of N-hydroxy-N-methyl-4-aminoazobenzene and other N-hydroxy arylamines to reactive sulfuric acid esters. Kadlubar, F.F., Miller, J.A., Miller, E.C. Cancer Res. (1976) [Pubmed]
  19. Cell-free synthesis of anticoagulant heparan sulfate reveals a limiting converting activity that modifies an excess precursor pool. Shworak, N.W., Fritze, L.M., Liu, J., Butler, L.D., Rosenberg, R.D. J. Biol. Chem. (1996) [Pubmed]
  20. Sulfation of chondroitin oligosaccharides in vitro. Analysis of sulfation ratios. Delfert, D.M., Conrad, H.E. J. Biol. Chem. (1985) [Pubmed]
  21. Morphological, biochemical, and functional characterization of bulk isolated glial progenitor cells. Lubetzki, C., Goujet-Zalc, C., Gansmüller, A., Monge, M., Brillat, A., Zalc, B. J. Neurochem. (1991) [Pubmed]
  22. Rapid sulfation of 3,3',5'-triiodothyronine in native Xenopus laevis oocytes. Friesema, E.C., Docter, R., Krenning, E.P., Everts, M.E., Hennemann, G., Visser, T.J. Endocrinology (1998) [Pubmed]
  23. Hepatic dopamine sulfotransferases in untreated rats and in rats subjected to endocrine or hypertension-related treatments. Singer, S.S., Palmert, M.R., Redman, M.D., Leahy, D.M., Feeser, T.C., Lucarelli, M.J., Volkwein, L.S., Bruns, M. Hepatology (1988) [Pubmed]
  24. Alpha-hydroxytamoxifen is a substrate of hydroxysteroid (alcohol) sulfotransferase, resulting in tamoxifen DNA adducts. Shibutani, S., Dasaradhi, L., Terashima, I., Banoglu, E., Duffel, M.W. Cancer Res. (1998) [Pubmed]
  25. The metabolic activation of the carcinogen 1'-hydroxysafrole in vivo and in vitro and the electrophilic reactivities of possible ultimate carcinogens. Wislocki, P.G., Borchert, P., Miller, J.A., Miller, E.C. Cancer Res. (1976) [Pubmed]
  26. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. Ouyang, Y.B., Moore, K.L. J. Biol. Chem. (1998) [Pubmed]
  27. Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. Chang, H.J., Shi, R., Rehse, P., Lin, S.X. J. Biol. Chem. (2004) [Pubmed]
  28. Inhibition of M and P phenol sulfotransferase by analogues of 3'-phosphoadenosine-5'-phosphosulfate. Rens-Domiano, S.S., Roth, J.A. J. Neurochem. (1987) [Pubmed]
  29. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) pharmacogenetics: gene resequencing, genetic polymorphisms and functional characterization of variant allozymes. Xu, Z.H., Freimuth, R.R., Eckloff, B., Wieben, E., Weinshilboum, R.M. Pharmacogenetics (2002) [Pubmed]
  30. Molecular characterization of ST1C1-related human sulfotransferase. Yoshinari, K., Nagata, K., Shimada, M., Yamazoe, Y. Carcinogenesis (1998) [Pubmed]
  31. Pharmacogenetics of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1): gene resequencing, sequence variation, and functional genomics. Xu, Z.H., Thomae, B.A., Eckloff, B.W., Wieben, E.D., Weinshilboum, R.M. Biochem. Pharmacol. (2003) [Pubmed]
  32. Interactions between dietary chemicals and human sulfotransferases-molecular mechanisms and clinical significance. Coughtrie, M.W., Johnston, L.E. Drug Metab. Dispos. (2001) [Pubmed]
  33. Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter. Kamiyama, S., Suda, T., Ueda, R., Suzuki, M., Okubo, R., Kikuchi, N., Chiba, Y., Goto, S., Toyoda, H., Saigo, K., Watanabe, M., Narimatsu, H., Jigami, Y., Nishihara, S. J. Biol. Chem. (2003) [Pubmed]
  34. Characterization and mutagenesis of Gal/GlcNAc-6-O-sulfotransferases. Grunwell, J.R., Rath, V.L., Rasmussen, J., Cabrilo, Z., Bertozzi, C.R. Biochemistry (2002) [Pubmed]
  35. Expression, purification and crystallization of human 3'-phosphoadenosine-5'-phosphosulfate synthetase 1. Harjes, S., Scheidig, A., Bayer, P. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  36. The assay of ATP-sulfurylase. Hommes, F.A., Moss, L. Anal. Biochem. (1986) [Pubmed]
  37. Sulfur uptake in the ectomycorrhizal fungus Laccaria bicolor S238N. Mansouri-Bauly, H., Kruse, J., Sýkorová, Z., Scheerer, U., Kopriva, S. Mycorrhiza (2006) [Pubmed]
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