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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Krt23  -  keratin 23

Mus musculus

Synonyms: CK-23, CK23, Cytokeratin-23, Haik1, K23, ...
 
 
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Disease relevance of Krt23

  • Mouse lymphoma L5178Y cells express at least two isoforms of beta-tubulin, designated M beta I and M beta II, as revealed by isoelectrofocusing, whereas two independently isolated normal T-cell clones, 3D10 and K23, express only M beta I [1].
  • Using a combination of antibodies and RT-PCR, we identified additional keratins expressed in the mouse cornea including K23 which was previously thought to be specific for pancreatic carcinomas [2].
  • Monoclonal antibodies (MoAbs) were raised against the tick-borne encephalitis (TBE) virus, strain K23 [3].
 

High impact information on Krt23

  • In isolated nuclei from 4T001 (gamma 2b) and K23 (gamma 2a) myeloma cells, the secretory-encoding mRNA polyadenylation site was used at least three times as often as the membrane-encoding mRNA polyadenylation site [4].

References

  1. Occurrence of two beta-tubulin isoforms with different polymerizing abilities in L5178Y cells. Harada, F., Matsuzaki, F., Yahara, I. Exp. Cell Res. (1986) [Pubmed]
  2. Keratin 5 knockout mice reveal plasticity of keratin expression in the corneal epithelium. Lu, H., Zimek, A., Chen, J., Hesse, M., Büssow, H., Weber, K., Magin, T.M. Eur. J. Cell Biol. (2006) [Pubmed]
  3. Monoclonal antibodies directed against tick-borne encephalitis virus with neutralizing activity in vivo. Niedrig, M., Klockmann, U., Lang, W., Roeder, J., Burk, S., Modrow, S., Pauli, G. Acta Virol. (1994) [Pubmed]
  4. Cell-specific expression of secreted versus membrane forms of immunoglobulin gamma 2b mRNA involves selective use of alternate polyadenylation sites. Milcarek, C., Hall, B. Mol. Cell. Biol. (1985) [Pubmed]
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