Disease relevance of KRT23

• K23 mRNA was highly induced by NaBu in different pancreatic cancer cells [1].
• A bacteriophage growing on Escherichia coli K13, K20, and K23 strains carries a glycanase that catalyzes the hydrolytic cleavage of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonic acid (KDO) in the respective capsular polysaccharides [2].
• Sequencing analysis showed that two car operons and the neighboring regions of Pseudomonas sp. strain K23 are nearly identical to that of strain CA10 [3].

Psychiatry related information on KRT23

• METHODS: The NIH CRISP database identified all NIMH Level-1 career awards (K01/K07/K08/K23/ R29) in geriatric mental health completed from 1992 to 2001 [4].

High impact information on KRT23

• A mechanism for the observed cooperation between acetylation and arginine methylation comes from the finding that acetylation at K18 and K23, but not K14, tethers recombinant CARM1 to the H3 tail and allows it to act as a more efficient arginine methyltransferase [5].
• Following these events, K23 is acetylated, CARM1 associates with chromatin, and methylation at R17 takes place [5].
• The draft covers nearly all previously established IF genes including the recent cDNA and gene additions, such as pancreatic keratin 23, synemin and the novel muscle protein syncoilin [6].
• Treatment with either actinomycin D or cycloheximide efficiently blocked the induction of K23 mRNA by NaBu/TSA [1].
• A comparison of the degrees of cold tolerance of the NILs indicated that Ctb1 is located in the 56-kb region covered by a bacterial artificial chromosome clone, OSJNBa0058 K23, that had been sequenced by the International Rice Genome Sequence Project. We found seven open reading frames (ORFs) in the 56-kb region [7].

Biological context of KRT23

• However, it is suggested that certain O and K antigens (O2,O6, K23) may be associated with virulence for the urinary tract [8].
• The two representative strains, Katano virus K23 and K24, have been analyzed by sequencing the open reading frame 2 (ORF2) region after amplification by reverse transcription-polymerase chain reaction (RT-PCR) [9].
• There was 94% nucleotide sequence identity and 95% amino acid sequence identity between K23 and K24, with the Oxford strains belonging to HAstV T6 [9].
• The authors gratefully acknowledge the support for this research provided by ARUP (Associated Regional and University Pathologists) Institute. This work was additionally supported by grants from the Dermatology Foundation Clinical Career Development Award (SRF) and National Institutes of Health Grant K23 RR17525-01 (SRF) [10].
• In contrast to strains CA10 and K23, carEF genes did not exist downstream of the car gene cluster of Janthinobacterium sp. strain J3 [3].

Associations of KRT23 with chemical compounds

• These results indicate that K23 mRNA induction by NaBu or TSA is a downstream event of histone hyperacetylation [1].
• The main cleavage product of the K23 polysaccharide has been identified by 1H- and 13C-n.m.r. spectroscopy as beta beta Ribfl----7 beta KDOp2----3-beta Ribfl----7KDO [2].

Analytical, diagnostic and therapeutic context of KRT23

• Intraperitoneal injection into mice of 10(3) cfu of K. pneumoniae producing both virulence factors demonstrated that capsular serotype K2 was the more virulent K23 and K28 [11].

References