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Gene Review

KRT23  -  keratin 23, type I

Homo sapiens

Synonyms: CK-23, CK23, Cytokeratin-23, DKFZP434G032, HAIK1, ...
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Disease relevance of KRT23


Psychiatry related information on KRT23

  • METHODS: The NIH CRISP database identified all NIMH Level-1 career awards (K01/K07/K08/K23/ R29) in geriatric mental health completed from 1992 to 2001 [4].

High impact information on KRT23

  • A mechanism for the observed cooperation between acetylation and arginine methylation comes from the finding that acetylation at K18 and K23, but not K14, tethers recombinant CARM1 to the H3 tail and allows it to act as a more efficient arginine methyltransferase [5].
  • Following these events, K23 is acetylated, CARM1 associates with chromatin, and methylation at R17 takes place [5].
  • The draft covers nearly all previously established IF genes including the recent cDNA and gene additions, such as pancreatic keratin 23, synemin and the novel muscle protein syncoilin [6].
  • Treatment with either actinomycin D or cycloheximide efficiently blocked the induction of K23 mRNA by NaBu/TSA [1].
  • A comparison of the degrees of cold tolerance of the NILs indicated that Ctb1 is located in the 56-kb region covered by a bacterial artificial chromosome clone, OSJNBa0058 K23, that had been sequenced by the International Rice Genome Sequence Project. We found seven open reading frames (ORFs) in the 56-kb region [7].

Biological context of KRT23

  • However, it is suggested that certain O and K antigens (O2,O6, K23) may be associated with virulence for the urinary tract [8].
  • The two representative strains, Katano virus K23 and K24, have been analyzed by sequencing the open reading frame 2 (ORF2) region after amplification by reverse transcription-polymerase chain reaction (RT-PCR) [9].
  • There was 94% nucleotide sequence identity and 95% amino acid sequence identity between K23 and K24, with the Oxford strains belonging to HAstV T6 [9].
  • The authors gratefully acknowledge the support for this research provided by ARUP (Associated Regional and University Pathologists) Institute. This work was additionally supported by grants from the Dermatology Foundation Clinical Career Development Award (SRF) and National Institutes of Health Grant K23 RR17525-01 (SRF) [10].
  • In contrast to strains CA10 and K23, carEF genes did not exist downstream of the car gene cluster of Janthinobacterium sp. strain J3 [3].

Associations of KRT23 with chemical compounds

  • These results indicate that K23 mRNA induction by NaBu or TSA is a downstream event of histone hyperacetylation [1].
  • The main cleavage product of the K23 polysaccharide has been identified by 1H- and 13C-n.m.r. spectroscopy as beta beta Ribfl----7 beta KDOp2----3-beta Ribfl----7KDO [2].

Analytical, diagnostic and therapeutic context of KRT23


  1. Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells. Zhang, J.S., Wang, L., Huang, H., Nelson, M., Smith, D.I. Genes Chromosomes Cancer (2001) [Pubmed]
  2. A bacteriophage-associated glycanase cleaving beta-pyranosidic linkages of 3-deoxy-D-manno-2-octulosonic acid (KDO). Altmann, F., Kwiatkowski, B., Stirm, S., März, L., Unger, F.M. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  3. Divergent structures of carbazole degradative car operons isolated from gram-negative bacteria. Inoue, K., Widada, J., Nakai, S., Endoh, T., Urata, M., Ashikawa, Y., Shintani, M., Saiki, Y., Yoshida, T., Habe, H., Omori, T., Nojiri, H. Biosci. Biotechnol. Biochem. (2004) [Pubmed]
  4. Challenges to the transition to independent investigator in geriatric mental health. Bruce, M.L. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. (2003) [Pubmed]
  5. Crosstalk between CARM1 methylation and CBP acetylation on histone H3. Daujat, S., Bauer, U.M., Shah, V., Turner, B., Berger, S., Kouzarides, T. Curr. Biol. (2002) [Pubmed]
  6. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. Hesse, M., Magin, T.M., Weber, K. J. Cell. Sci. (2001) [Pubmed]
  7. Physical mapping and putative candidate gene identification of a quantitative trait locus Ctb1 for cold tolerance at the booting stage of rice. Saito, K., Hayano-Saito, Y., Maruyama-Funatsuki, W., Sato, Y., Kato, A. Theor. Appl. Genet. (2004) [Pubmed]
  8. Virulence of Escherichia coli strains isolated from urine of patients with acute cystitis and from faeces of healthy women. van den Bosch, J.F., Postma, P., van Brenk, D., Guinée, P.A., de Graaff, J., MacLaren, D.M. Antonie Van Leeuwenhoek (1981) [Pubmed]
  9. Genomic characterization of human astrovirus type 6 Katano virus and the establishment of a rapid and effective reverse transcription-polymerase chain reaction to detect all serotypes of human astrovirus. Sakon, N., Yamazaki, K., Utagawa, E., Okuno, Y., Oishi, I. J. Med. Virol. (2000) [Pubmed]
  10. Cost-Effective Dynamic Telepathology in the Mohs Surgery Laboratory Utilizing iChat AV Videoconferencing Software. McKenna, J.K., Florell, S.R. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (2007) [Pubmed]
  11. Virulence factors (aerobactin and mucoid phenotype) in Klebsiella pneumoniae and Escherichia coli blood culture isolates. Vernet, V., Philippon, A., Madoulet, C., Vistelle, R., Jaussaud, R., Chippaux, C. FEMS Microbiol. Lett. (1995) [Pubmed]
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