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Gene Review

fabZ  -  (3R)-hydroxymyristol acyl carrier protein...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0179, JW0175, sabA, sefA, sfhC, ...
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Disease relevance of fabZ

  • The suppressor mutation, named sfhC21, that allows Escherichia coli ftsH null mutant cells to survive was found to be an allele of fabZ encoding R-3-hydroxyacyl-ACP dehydrase, involved in a key step of fatty acid biosynthesis, and appears to upregulate the dehydrase [1].
  • These genes show homology to fabZ and accB from E. coli and Bacillus subtilis, respectively, both involved in fatty acids biosynthesis [2].
  • Preliminary evaluation of the use of the sefA fimbrial gene to elicit immune response against Salmonella enterica serotype Enteritidis in chickens [3].

High impact information on fabZ

  • A mutation, sabA1, that reverses the MacConkey sensitivity phenotype of asmB1 maps within fabZ (whose product is needed for phospholipid synthesis from a precursor) is also required for lipid A synthesis [4].
  • Cloning and sequence analysis of chromosomal DNA downstream of lpxD revealed the presence of the fabZ and lpxA genes [5].
  • The tolZ21 mutant was found to have a suppressor mutation, named sfhC, which allowed cells to survive [6].
  • Primer extension analysis of sefABC revealed two major transcription start sites located upstream of sefA [7].
  • Transcription of sefBC also initiated from the sefA promoter region [7].

Biological context of fabZ


  1. Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli. Ogura, T., Inoue, K., Tatsuta, T., Suzaki, T., Karata, K., Young, K., Su, L.H., Fierke, C.A., Jackman, J.E., Raetz, C.R., Coleman, J., Tomoyasu, T., Matsuzawa, H. Mol. Microbiol. (1999) [Pubmed]
  2. Maltose metabolism of Lactobacillus sanfranciscensis: cloning and heterologous expression of the key enzymes, maltose phosphorylase and phosphoglucomutase. Ehrmann, M.A., Vogel, R.F. FEMS Microbiol. Lett. (1998) [Pubmed]
  3. Preliminary evaluation of the use of the sefA fimbrial gene to elicit immune response against Salmonella enterica serotype Enteritidis in chickens. Lopes, V.C., Velayudhan, B.T., Halvorson, D.A., Nagaraja, K.V. Avian Dis. (2006) [Pubmed]
  4. Modulations in lipid A and phospholipid biosynthesis pathways influence outer membrane protein assembly in Escherichia coli K-12. Kloser, A., Laird, M., Deng, M., Misra, R. Mol. Microbiol. (1998) [Pubmed]
  5. Isolation and characterization of the Neisseria meningitidis lpxD-fabZ-lpxA gene cluster involved in lipid A biosynthesis. Steeghs, L., Jennings, M.P., Poolman, J.T., van der Ley, P. Gene (1997) [Pubmed]
  6. The tolZ gene of Escherichia coli is identified as the ftsH gene. Qu, J.N., Makino, S.I., Adachi, H., Koyama, Y., Akiyama, Y., Ito, K., Tomoyasu, T., Ogura, T., Matsuzawa, H. J. Bacteriol. (1996) [Pubmed]
  7. Characterization of three fimbrial genes, sefABC, of Salmonella enteritidis. Clouthier, S.C., Müller, K.H., Doran, J.L., Collinson, S.K., Kay, W.W. J. Bacteriol. (1993) [Pubmed]
  8. Cloning, DNA nucleotide sequence and distribution of the gene encoding the SEF14 fimbrial antigen of Salmonella enteritidis. Turcotte, C., Woodward, M.J. J. Gen. Microbiol. (1993) [Pubmed]
  9. Defective plasmid partition in ftsH mutants of Escherichia coli. Inagawa, T., Kato, J., Niki, H., Karata, K., Ogura, T. Mol. Genet. Genomics (2001) [Pubmed]
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