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Gene Review

lpxA  -  UDP-N-acetylglucosamine acetyltransferase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0180, JW0176
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Disease relevance of lpxA


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Chemical compound and disease context of lpxA


Biological context of lpxA


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  1. Molecular cloning of the genes for lipid A disaccharide synthase and UDP-N-acetylglucosamine acyltransferase in Escherichia coli. Crowell, D.N., Anderson, M.S., Raetz, C.R. J. Bacteriol. (1986) [Pubmed]
  2. Shortened hydroxyacyl chains on lipid A of Escherichia coli cells expressing a foreign UDP-N-acetylglucosamine O-acyltransferase. Odegaard, T.J., Kaltashov, I.A., Cotter, R.J., Steeghs, L., van der Ley, P., Khan, S., Maskell, D.J., Raetz, C.R. J. Biol. Chem. (1997) [Pubmed]
  3. Expression cloning of a Pseudomonas gene encoding a hydroxydecanoyl-acyl carrier protein-dependent UDP-GlcNAc acyltransferase. Dotson, G.D., Kaltashov, I.A., Cotter, R.J., Raetz, C.R. J. Bacteriol. (1998) [Pubmed]
  4. Differentiation of Campylobacter coli, Campylobacter jejuni, Campylobacter lari, and Campylobacter upsaliensis by a multiplex PCR developed from the nucleotide sequence of the lipid A gene lpxA. Klena, J.D., Parker, C.T., Knibb, K., Ibbitt, J.C., Devane, P.M., Horn, S.T., Miller, W.G., Konkel, M.E. J. Clin. Microbiol. (2004) [Pubmed]
  5. A Chlamydia trachomatis UDP-N-acetylglucosamine acyltransferase selective for myristoyl-acyl carrier protein. Expression in Escherichia coli and formation of hybrid lipid A species. Sweet, C.R., Lin, S., Cotter, R.J., Raetz, C.R. J. Biol. Chem. (2001) [Pubmed]
  6. Oxidation and transamination of the 3"-position of UDP-N-acetylglucosamine by enzymes from Acidithiobacillus ferrooxidans. Role in the formation of lipid a molecules with four amide-linked acyl chains. Sweet, C.R., Ribeiro, A.A., Raetz, C.R. J. Biol. Chem. (2004) [Pubmed]
  7. The firA gene of Escherichia coli encodes UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase. The third step of endotoxin biosynthesis. Kelly, T.M., Stachula, S.A., Raetz, C.R., Anderson, M.S. J. Biol. Chem. (1993) [Pubmed]
  8. Isolation and characterization of the Neisseria meningitidis lpxD-fabZ-lpxA gene cluster involved in lipid A biosynthesis. Steeghs, L., Jennings, M.P., Poolman, J.T., van der Ley, P. Gene (1997) [Pubmed]
  9. Crystallization of UDP-N-acetylglucosamine O-acyltransferase from Escherichia coli. Pfitzner, U., Raetz, C.R., Roderick, S.L. Proteins (1995) [Pubmed]
  10. Cloning and expression of the Borrelia burgdorferi lon gene. Cloud, J.L., Marconi, R.T., Eggers, C.H., Garon, C.F., Tilly, K., Samuels, D.S. Gene (1997) [Pubmed]
  11. kdsA mutations affect FtsZ-ring formation in Escherichia coli K-12. Fujishima, H., Nishimura, A., Wachi, M., Takagi, H., Hirasawa, T., Teraoka, H., Nishimori, K., Kawabata, T., Nishikawa, K., Nagai, K. Microbiology (Reading, Engl.) (2002) [Pubmed]
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