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Gene Review

purK  -  N5-carboxyaminoimidazole ribonucleotide...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0515, JW0511, purE2
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Disease relevance of purK

  • The avian enzyme lacks sequences corresponding to purK yet functions in E. coli [1].

High impact information on purK

  • In E. coli, AIR carboxylase is the product of genes purEK with the purK subunit postulated to have a role in CO2 binding [1].
  • However, the purT protein shows significant homology to the purK protein, also involved in purine biosynthesis [2].
  • Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway [3].

Chemical compound and disease context of purK


Biological context of purK


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