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Gene Review

fepC  -  ferrienterobactin ABC transporter ATPase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0581, JW0580
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High impact information on fepC

  • In vitro transcription-translation analysis identified polypeptides of 30 and 35 kDa encoded by fepC and fes, respectively [1].
  • It is proposed that these newly identified genes, fepD and fepE, provide functions which act in conjunction with the fepC product to form the ferric enterobactin-specific cytoplasmic membrane permease [2].
  • Minicell, maxicell, and in vitro DNA-directed protein synthesizing systems were used to identify the fepB and fepC products [3].
  • The deletions, all of which eliminated approximately the left half of the enterobactin gene cluster, extended from the vicinity of the fepC gene counterclockwise into the chromosome [4].


  1. Ferric enterochelin transport in Yersinia enterocolitica: molecular and evolutionary aspects. Schubert, S., Fischer, D., Heesemann, J. J. Bacteriol. (1999) [Pubmed]
  2. Genetic organization of multiple fep genes encoding ferric enterobactin transport functions in Escherichia coli. Ozenberger, B.A., Nahlik, M.S., McIntosh, M.A. J. Bacteriol. (1987) [Pubmed]
  3. Escherichia coli K-12 envelope proteins specifically required for ferrienterobactin uptake. Pierce, J.R., Earhart, C.F. J. Bacteriol. (1986) [Pubmed]
  4. Biochemical analysis of spontaneous fepA mutants of Escherichia coli. Elish, M.E., Pierce, J.R., Earhart, C.F. J. Gen. Microbiol. (1988) [Pubmed]
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