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Gene Review

fes  -  enterobactin/ferrienterobactin esterase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0577, JW0576
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Disease relevance of fes


High impact information on fes

  • In contrast, p92c-fes immunoprecipitated from these Rat-2 cells or expressed as an enzymatically active fragment in Escherichia coli from a c-fps/fes cDNA catalyzed tyrosine phosphorylation with an activity similar to that of v-fps/fes polypeptides [3].
  • Proteins encoded by oncogenes such as v-fps/fes, v-src, v-yes, v-abl, and v-fgr are cytoplasmic protein tyrosine kinases which, unlike transmembrane receptors, are localized to the inside of the cell [4].
  • The Escherichia coli ferric enterobactin esterase gene (fes) was cloned into the vector pGEM3Z under the control of the T7 gene 10 promoter and overexpressed to approximately 15% of the total cellular protein [5].
  • Transcriptional mapping and nucleotide sequence of the Escherichia coli fepA-fes enterobactin region. Identification of a unique iron-regulated bidirectional promoter [6].
  • An additional small open reading frame of 216 nucleotides (encoding a potential product of calculated Mr 8,271) was also identified between fes and entF [6].

Chemical compound and disease context of fes


Biological context of fes


Associations of fes with chemical compounds

  • Thus, enterobactin protects against colicins V and Ia, but only when the colicin indicator strain is fes+, and hydroxamate siderophores inhibit colicins B, V, and Ia, but only when the colicin indicator strain is SidA+ [10].
  • Growth in citrate plus iron (1.8 muM) or in ferrichrome resulted in a substantial reduction in both receptor levels and Ia sensitivity in ent, fes, and fep strains but had no effect on receptor levels in tonB strains [11].

Other interactions of fes

  • In vitro transcription-translation analysis identified polypeptides of 30 and 35 kDa encoded by fepC and fes, respectively [1].


  1. Ferric enterochelin transport in Yersinia enterocolitica: molecular and evolutionary aspects. Schubert, S., Fischer, D., Heesemann, J. J. Bacteriol. (1999) [Pubmed]
  2. Analysis of the Erwinia chrysanthemi ferrichrysobactin receptor gene: resemblance to the Escherichia coli fepA-fes bidirectional promoter region and homology with hydroxamate receptors. Sauvage, C., Franza, T., Expert, D. J. Bacteriol. (1996) [Pubmed]
  3. The human c-fps/fes gene product expressed ectopically in rat fibroblasts is nontransforming and has restrained protein-tyrosine kinase activity. Greer, P.A., Meckling-Hansen, K., Pawson, T. Mol. Cell. Biol. (1988) [Pubmed]
  4. A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps. Sadowski, I., Stone, J.C., Pawson, T. Mol. Cell. Biol. (1986) [Pubmed]
  5. Overexpression and purification of ferric enterobactin esterase from Escherichia coli. Demonstration of enzymatic hydrolysis of enterobactin and its iron complex. Brickman, T.J., McIntosh, M.A. J. Biol. Chem. (1992) [Pubmed]
  6. Transcriptional mapping and nucleotide sequence of the Escherichia coli fepA-fes enterobactin region. Identification of a unique iron-regulated bidirectional promoter. Pettis, G.S., Brickman, T.J., McIntosh, M.A. J. Biol. Chem. (1988) [Pubmed]
  7. HPLC separation of enterobactin and linear 2,3-dihydroxybenzoylserine derivatives: a study on mutants of Escherichia coli defective in regulation (fur), esterase (fes) and transport (fepA). Winkelmann, G., Cansier, A., Beck, W., Jung, G. Biometals (1994) [Pubmed]
  8. Physical and genetic characterization of cloned enterobactin genomic sequences from Escherichia coli K-12. Fleming, T.P., Nahlik, M.S., Neilands, J.B., McIntosh, M.A. Gene (1985) [Pubmed]
  9. Molecular characterization of the Escherichia coli enterobactin cistron entF and coupled expression of entF and the fes gene. Pettis, G.S., McIntosh, M.A. J. Bacteriol. (1987) [Pubmed]
  10. Siderophore protection against colicins M, B, V, and Ia in Escherichia coli. Wayne, R., Frick, K., Neilands, J.B. J. Bacteriol. (1976) [Pubmed]
  11. Relationship between the transport of iron and the amount of specific colicin Ia membrane receptors in Escherichia coli. Konisky, J., Soucek, S., Frick, K., Davies, J.K., Hammond, C. J. Bacteriol. (1976) [Pubmed]
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