Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

sdhB - succinate dehydrogenase, FeS subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0713, JW0714

Darlison, M.G. et al., Wood, D. et al., Magnusson, K. et al.

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Disease relevance of sdhB

The nucleotide sequence of a 961 base-pair segment of DNA containing the sdhB gene, which encodes the iron-sulphur protein subunit of the E. coli succinate dehydrogenase, has been determined [1].

High impact information on sdhB

The sdhB structural gene encodes a polypeptide of Mr26637 that is strikingly homologous with the iron-sulphur protein subunit of fumarate reductase (38% identity, increasing to 58% when conservative changes are included) [1].
The sdhB structural gene comprises 711 base pairs (237 codons, excluding the translational initiator and terminator) [1].
Together with the iron-sulphur protein gene (sdhB) these genes form an operon (sdhCDAB) situated between the citrate synthase gene (gltA) and the 2-oxoglutarate dehydrogenase complex genes (sucAB): gltA-sdhCDAB-sucAB [2].

Associations of sdhB with chemical compounds

The nucleotide sequence predicts the presence of a typical flavin-binding peptide which identifies this reading frame as part of the sdhB gene [3].

References

Nucleotide sequence encoding the iron-sulphur protein subunit of the succinate dehydrogenase of Escherichia coli. Darlison, M.G., Guest, J.R. Biochem. J. (1984) [Pubmed]
Nucleotide sequence encoding the flavoprotein and hydrophobic subunits of the succinate dehydrogenase of Escherichia coli. Wood, D., Darlison, M.G., Wilde, R.J., Guest, J.R. Biochem. J. (1984) [Pubmed]
Nucleotide sequence of the gene for cytochrome b558 of the Bacillus subtilis succinate dehydrogenase complex. Magnusson, K., Philips, M.K., Guest, J.R., Rutberg, L. J. Bacteriol. (1986) [Pubmed]

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