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Gene Review

gltA  -  citrate synthase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0709, JW0710, gluT, icdB
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Disease relevance of gltA


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Chemical compound and disease context of gltA


Biological context of gltA


Associations of gltA with chemical compounds


Regulatory relationships of gltA


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Analytical, diagnostic and therapeutic context of gltA


  1. Nucleotide sequence of the promoter region of the citrate synthase gene (gltA) of Escherichia coli. Hull, E.P., Spencer, M.E., Wood, D., Guest, J.R. FEBS Lett. (1983) [Pubmed]
  2. The citrate synthase-encoding gene of Rickettsia prowazekii is controlled by two promoters. Cai, J., Pang, H., Wood, D.O., Winkler, H.H. Gene (1995) [Pubmed]
  3. Molecular cloning of four tricarboxylic acid cyclic genes of Escherichia coli. Spencer, M.E., Guest, J.R. J. Bacteriol. (1982) [Pubmed]
  4. Citrate synthase mutants of Sinorhizobium meliloti are ineffective and have altered cell surface polysaccharides. Mortimer, M.W., McDermott, T.R., York, G.M., Walker, G.C., Kahn, M.L. J. Bacteriol. (1999) [Pubmed]
  5. Positive regulation of glutamate biosynthesis in Bacillus subtilis. Bohannon, D.E., Sonenshein, A.L. J. Bacteriol. (1989) [Pubmed]
  6. Isolation of the nuclear yeast genes for citrate synthase and fifteen other mitochondrial proteins by a new screening method. Suissa, M., Suda, K., Schatz, G. EMBO J. (1984) [Pubmed]
  7. Expression of Mycobacterium leprae genes from a Streptococcus mutans promoter in Escherichia coli K-12. Jacobs, W.R., Docherty, M.A., Curtiss, R., Clark-Curtiss, J.E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  8. Characterization of rate-controlling steps in vivo by use of an adjustable expression vector. Walsh, K., Koshland, D.E. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  9. Probing the roles of key residues in the unique regulatory NADH binding site of type II citrate synthase of Escherichia coli. Stokell, D.J., Donald, L.J., Maurus, R., Nguyen, N.T., Sadler, G., Choudhary, K., Hultin, P.G., Brayer, G.D., Duckworth, H.W. J. Biol. Chem. (2003) [Pubmed]
  10. The gene for gamma-glutamylcysteine synthetase from Thiobacillus ferrooxidans has low homology to its Escherichia coli equivalent and is linked to the gene for citrate synthase. Powles, R., Deane, S., Rawlings, D. Microbiology (Reading, Engl.) (1996) [Pubmed]
  11. The role of cysteine 206 in allosteric inhibition of Escherichia coli citrate synthase. Studies by chemical modification, site-directed mutagenesis, and 19F NMR. Donald, L.J., Crane, B.R., Anderson, D.H., Duckworth, H.W. J. Biol. Chem. (1991) [Pubmed]
  12. Compensatory regulation in metabolic pathways--responses to increases and decreases in citrate synthase levels. Walsh, K., Schena, M., Flint, A.J., Koshland, D.E. Biochem. Soc. Symp. (1987) [Pubmed]
  13. Comparative analysis of folding and substrate binding sites between regulated hexameric type II citrate synthases and unregulated dimeric type I enzymes. Nguyen, N.T., Maurus, R., Stokell, D.J., Ayed, A., Duckworth, H.W., Brayer, G.D. Biochemistry (2001) [Pubmed]
  14. In vitro mutagenesis of Escherichia coli citrate synthase to clarify the locations of ligand binding sites. Anderson, D.H., Duckworth, H.W. J. Biol. Chem. (1988) [Pubmed]
  15. Regulation of the citrate synthase (gltA) gene of Escherichia coli in response to anaerobiosis and carbon supply: role of the arcA gene product. Park, S.J., McCabe, J., Turna, J., Gunsalus, R.P. J. Bacteriol. (1994) [Pubmed]
  16. Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii. Heinzen, R.A., Mo, Y.Y., Robertson, S.J., Mallavia, L.P. Gene (1995) [Pubmed]
  17. Does Escherichia coli possess a second citrate synthase gene? Patton, A.J., Hough, D.W., Towner, P., Danson, M.J. Eur. J. Biochem. (1993) [Pubmed]
  18. Nucleotide sequence encoding the flavoprotein and hydrophobic subunits of the succinate dehydrogenase of Escherichia coli. Wood, D., Darlison, M.G., Wilde, R.J., Guest, J.R. Biochem. J. (1984) [Pubmed]
  19. Citrate synthase and 2-methylcitrate synthase: structural, functional and evolutionary relationships. Gerike, U., Hough, D.W., Russell, N.J., Dyall-Smith, M.L., Danson, M.J. Microbiology (Reading, Engl.) (1998) [Pubmed]
  20. Gene cloning, sequencing and enzymatic properties of glutamate synthase from the hyperthermophilic archaeon Pyrococcus sp. KOD1. Jongsareejit, B., Rahman, R.N., Fujiwara, S., Imanaka, T. Mol. Gen. Genet. (1997) [Pubmed]
  21. Metabolic characterisation of E. coli citrate synthase and phosphoenolpyruvate carboxylase mutants in aerobic cultures. De Maeseneire, S.L., De Mey, M., Vandedrinck, S., Vandamme, E.J. Biotechnol. Lett. (2006) [Pubmed]
  22. Role of the citrate pathway in glutamate biosynthesis by Streptococcus mutans. Cvitkovitch, D.G., Gutierrez, J.A., Bleiweis, A.S. J. Bacteriol. (1997) [Pubmed]
  23. Alterations of Cellular Physiology in Escherichia coli in Response to Oxidative Phosphorylation Impaired by Defective F1-ATPase. Noda, S., Takezawa, Y., Mizutani, T., Asakura, T., Nishiumi, E., Onoe, K., Wada, M., Tomita, F., Matsushita, K., Yokota, A. J. Bacteriol. (2006) [Pubmed]
  24. Identification of two distinct Bacillus subtilis citrate synthase genes. Jin, S., Sonenshein, A.L. J. Bacteriol. (1994) [Pubmed]
  25. Characterization of citrate synthase from Geobacter sulfurreducens and evidence for a family of citrate synthases similar to those of eukaryotes throughout the Geobacteraceae. Bond, D.R., Mester, T., Nesbø, C.L., Izquierdo-Lopez, A.V., Collart, F.L., Lovley, D.R. Appl. Environ. Microbiol. (2005) [Pubmed]
  26. Differentiation of Bartonella-like isolates at the species level by PCR-restriction fragment length polymorphism in the citrate synthase gene. Norman, A.F., Regnery, R., Jameson, P., Greene, C., Krause, D.C. J. Clin. Microbiol. (1995) [Pubmed]
  27. Cloning, sequencing, and expression of the gene for NADH-sensitive citrate synthase of Pseudomonas aeruginosa. Donald, L.J., Molgat, G.F., Duckworth, H.W. J. Bacteriol. (1989) [Pubmed]
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