Disease relevance of moaC

• The product of the moaC gene of strain PCC 7942 shows homology in its N-terminal half to MoaC from Escherichia coli and in its C-terminal half to MoaB or Mog [1].
• The sequence of a symbiotically essential Bradyrhizobium japonicum operon consisting of trpD, trpC and a moaC-like gene [2].

High impact information on moaC

• The proteins encoded by the Escherichia coli genes moaA and moaC catalyse the first steps in MoCo synthesis [3].
• Downstream of the tupABC genes, the genes moeA, moeA-1, moaA, and a truncated moaC have been identified by sequence comparison of the deduced amino acid sequences [4].
• The third ORF has a predicted product with 58% amino-acid sequence identity with the gene product of E. coli moaC, a gene encoding an enzyme involved in biosynthesis of the molybdenum cofactor required for the activity of nitrate reductase and other Mo cofactor-requiring enzymes [2].

Biological context of moaC

• The CNXA domain is similar at the amino acid level to the Escherichia coli moaA gene product, while CNXC is similar to the E. coli moaC product, with both E. coli products encoded by different cistrons [5].

References