The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

moaC  -  molybdopterin biosynthesis, protein C

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0772, JW0766
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of moaC


High impact information on moaC

  • The proteins encoded by the Escherichia coli genes moaA and moaC catalyse the first steps in MoCo synthesis [3].
  • Downstream of the tupABC genes, the genes moeA, moeA-1, moaA, and a truncated moaC have been identified by sequence comparison of the deduced amino acid sequences [4].
  • The third ORF has a predicted product with 58% amino-acid sequence identity with the gene product of E. coli moaC, a gene encoding an enzyme involved in biosynthesis of the molybdenum cofactor required for the activity of nitrate reductase and other Mo cofactor-requiring enzymes [2].

Biological context of moaC


  1. The narA locus of Synechococcus sp. strain PCC 7942 consists of a cluster of molybdopterin biosynthesis genes. Rubio, L.M., Flores, E., Herrero, A. J. Bacteriol. (1998) [Pubmed]
  2. The sequence of a symbiotically essential Bradyrhizobium japonicum operon consisting of trpD, trpC and a moaC-like gene. Kuykendall, L.D., Hunter, W.J. Biochim. Biophys. Acta (1997) [Pubmed]
  3. Mutations in a polycistronic nuclear gene associated with molybdenum cofactor deficiency. Reiss, J., Cohen, N., Dorche, C., Mandel, H., Mendel, R.R., Stallmeyer, B., Zabot, M.T., Dierks, T. Nat. Genet. (1998) [Pubmed]
  4. Tungstate Uptake by a highly specific ABC transporter in Eubacterium acidaminophilum. Makdessi, K., Andreesen, J.R., Pich, A. J. Biol. Chem. (2001) [Pubmed]
  5. The Aspergillus nidulans cnxABC locus is a single gene encoding two catalytic domains required for synthesis of precursor Z, an intermediate in molybdenum cofactor biosynthesis. Unkles, S.E., Smith, J., Kanan, G.J., Millar, L.J., Heck, I.S., Boxer, D.H., Kinghorn, J.R. J. Biol. Chem. (1997) [Pubmed]
WikiGenes - Universities