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Gene Review

moeA  -  molybdopterin molybdenumtransferase;...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0817, JW0811, bisB, chlE, narE
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Disease relevance of moeA


High impact information on moeA


Chemical compound and disease context of moeA


Biological context of moeA


Anatomical context of moeA

  • The nitrate reductase in the wild type was completely stable in vivo under inducing or noninducing conditions, whereas in the chlC and chlE mutants nitrate reductase was degraded extensively in both the cytoplasm and membranes, even under inducing conditions [10].

Associations of moeA with chemical compounds

  • Heat-treated preparations from chlA and chlE mutants which do not possess molybdenum cofactor activity fail to restore the activation [11].

Other interactions of moeA


Analytical, diagnostic and therapeutic context of moeA

  • E. coli JRG97 cells transformed with mutants that failed to restore nitrate reductase activity showed by HPLC analysis a decreased level of molybdopterin-derived dephospho FormA as compared to bacteria transformed with wild-type moeA [13].


  1. Physiological and genetic analyses leading to identification of a biochemical role for the moeA (molybdate metabolism) gene product in Escherichia coli. Hasona, A., Ray, R.M., Shanmugam, K.T. J. Bacteriol. (1998) [Pubmed]
  2. The narA locus of Synechococcus sp. strain PCC 7942 consists of a cluster of molybdopterin biosynthesis genes. Rubio, L.M., Flores, E., Herrero, A. J. Bacteriol. (1998) [Pubmed]
  3. Activity of the molybdopterin-containing xanthine dehydrogenase of Rhodobacter capsulatus can be restored by high molybdenum concentrations in a moeA mutant defective in molybdenum cofactor biosynthesis. Leimkühler, S., Angermüller, S., Schwarz, G., Mendel, R.R., Klipp, W. J. Bacteriol. (1999) [Pubmed]
  4. Molybdate reduction by Escherichia coli K-12 and its chl mutants. Campbell, A.M., del Campillo-Campbell, A., Villaret, D.B. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  5. Investigation of the early steps of molybdopterin biosynthesis in Escherichia coli through the use of in vivo labeling studies. Wuebbens, M.M., Rajagopalan, K.V. J. Biol. Chem. (1995) [Pubmed]
  6. ModE-dependent molybdate regulation of the molybdenum cofactor operon moa in Escherichia coli. Anderson, L.A., McNairn, E., Lubke, T., Pau, R.N., Boxer, D.H., Leubke, T. J. Bacteriol. (2000) [Pubmed]
  7. Molybdopterin guanine dinucleotide cofactor in Synechococcus sp. nitrate reductase: identification of mobA and isolation of a putative moeB gene. Rubio, L.M., Flores, E., Herrero, A. FEBS Lett. (1999) [Pubmed]
  8. Nitrate reductase in Escherichia coli K-12: involvement of chlC, chlE, and chlG loci. Stewart, V., MacGregor, C.H. J. Bacteriol. (1982) [Pubmed]
  9. Cloning and sequencing of the Escherichia coli chlEN operon involved in molybdopterin biosynthesis. Nohno, T., Kasai, Y., Saito, T. J. Bacteriol. (1988) [Pubmed]
  10. Synthesis and degradation of nitrate reductase in Escherichia coli. Hackett, C.S., MacGregor, C.H. J. Bacteriol. (1981) [Pubmed]
  11. Activation in vitro of respiratory nitrate reductase of Escherichia coli K12 grown in the presence of tungstate. Involvement of molybdenum cofactor. Saracino, L., Violet, M., Boxer, D.H., Giordano, G. Eur. J. Biochem. (1986) [Pubmed]
  12. Involvement of chlA, E, M, and N loci in Escherichia coli molybdopterin biosynthesis. Johnson, M.E., Rajagopalan, K.V. J. Bacteriol. (1987) [Pubmed]
  13. Functional analysis of the Escherichia coli molybdopterin cofactor biosynthesis protein MoeA by site-directed mutagenesis. Sandu, C., Brandsch, R. Biol. Chem. (2002) [Pubmed]
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