The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

moeA  -  molybdopterin molybdenumtransferase;...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0817, JW0811, bisB, chlE, narE
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of moeA

 

High impact information on moeA

 

Chemical compound and disease context of moeA

 

Biological context of moeA

 

Anatomical context of moeA

  • The nitrate reductase in the wild type was completely stable in vivo under inducing or noninducing conditions, whereas in the chlC and chlE mutants nitrate reductase was degraded extensively in both the cytoplasm and membranes, even under inducing conditions [10].
 

Associations of moeA with chemical compounds

  • Heat-treated preparations from chlA and chlE mutants which do not possess molybdenum cofactor activity fail to restore the activation [11].
 

Other interactions of moeA

 

Analytical, diagnostic and therapeutic context of moeA

  • E. coli JRG97 cells transformed with mutants that failed to restore nitrate reductase activity showed by HPLC analysis a decreased level of molybdopterin-derived dephospho FormA as compared to bacteria transformed with wild-type moeA [13].

References

  1. Physiological and genetic analyses leading to identification of a biochemical role for the moeA (molybdate metabolism) gene product in Escherichia coli. Hasona, A., Ray, R.M., Shanmugam, K.T. J. Bacteriol. (1998) [Pubmed]
  2. The narA locus of Synechococcus sp. strain PCC 7942 consists of a cluster of molybdopterin biosynthesis genes. Rubio, L.M., Flores, E., Herrero, A. J. Bacteriol. (1998) [Pubmed]
  3. Activity of the molybdopterin-containing xanthine dehydrogenase of Rhodobacter capsulatus can be restored by high molybdenum concentrations in a moeA mutant defective in molybdenum cofactor biosynthesis. Leimkühler, S., Angermüller, S., Schwarz, G., Mendel, R.R., Klipp, W. J. Bacteriol. (1999) [Pubmed]
  4. Molybdate reduction by Escherichia coli K-12 and its chl mutants. Campbell, A.M., del Campillo-Campbell, A., Villaret, D.B. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  5. Investigation of the early steps of molybdopterin biosynthesis in Escherichia coli through the use of in vivo labeling studies. Wuebbens, M.M., Rajagopalan, K.V. J. Biol. Chem. (1995) [Pubmed]
  6. ModE-dependent molybdate regulation of the molybdenum cofactor operon moa in Escherichia coli. Anderson, L.A., McNairn, E., Lubke, T., Pau, R.N., Boxer, D.H., Leubke, T. J. Bacteriol. (2000) [Pubmed]
  7. Molybdopterin guanine dinucleotide cofactor in Synechococcus sp. nitrate reductase: identification of mobA and isolation of a putative moeB gene. Rubio, L.M., Flores, E., Herrero, A. FEBS Lett. (1999) [Pubmed]
  8. Nitrate reductase in Escherichia coli K-12: involvement of chlC, chlE, and chlG loci. Stewart, V., MacGregor, C.H. J. Bacteriol. (1982) [Pubmed]
  9. Cloning and sequencing of the Escherichia coli chlEN operon involved in molybdopterin biosynthesis. Nohno, T., Kasai, Y., Saito, T. J. Bacteriol. (1988) [Pubmed]
  10. Synthesis and degradation of nitrate reductase in Escherichia coli. Hackett, C.S., MacGregor, C.H. J. Bacteriol. (1981) [Pubmed]
  11. Activation in vitro of respiratory nitrate reductase of Escherichia coli K12 grown in the presence of tungstate. Involvement of molybdenum cofactor. Saracino, L., Violet, M., Boxer, D.H., Giordano, G. Eur. J. Biochem. (1986) [Pubmed]
  12. Involvement of chlA, E, M, and N loci in Escherichia coli molybdopterin biosynthesis. Johnson, M.E., Rajagopalan, K.V. J. Bacteriol. (1987) [Pubmed]
  13. Functional analysis of the Escherichia coli molybdopterin cofactor biosynthesis protein MoeA by site-directed mutagenesis. Sandu, C., Brandsch, R. Biol. Chem. (2002) [Pubmed]
 
WikiGenes - Universities