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Gene Review:

acrD - aminoglycoside/multidrug efflux system

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2465, JW2454, yffA

Rosenberg, E.Y. et al., Elkins, C.A. et al., Nakamura, H.

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Disease relevance of acrD

Novel acriflavin resistance genes, acrC and acrD, in Escherichia coli K-12 [1].

High impact information on acrD

We used this knowledge to test several plasmid-encoded chimeric constructs of acrD and acrB for substrate specificity in a marR1 DeltaacrB DeltaacrD host [2].
Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of [(3)H]dihydrostreptomycin and [(3)H]gentamicin than did the parent strain [3].

References

Novel acriflavin resistance genes, acrC and acrD, in Escherichia coli K-12. Nakamura, H. J. Bacteriol. (1979) [Pubmed]
Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops. Elkins, C.A., Nikaido, H. J. Bacteriol. (2002) [Pubmed]
AcrD of Escherichia coli is an aminoglycoside efflux pump. Rosenberg, E.Y., Ma, D., Nikaido, H. J. Bacteriol. (2000) [Pubmed]

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