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Gene Review

galU  -  glucose-1-phosphate uridylyltransferase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1231, JW1224, verA, ychD
 
 
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Disease relevance of galU

 

High impact information on galU

  • The galU and rfe mutants invaded HeLa cells but failed to generate the membrane protrusions (fireworks) characteristic of intracellular motility displayed by wild-type shigellae [2].
  • Given the known structures of the LPS of wild-type S. flexneri 2a, the rfe mutant, and the galU mutant, we hypothesize that the core and O-antigen components of LPS are critical elements in the correct unipolar localization of IcsA [2].
  • The galU gene is located immediately downstream of the hns gene, and its open reading frame would be transcribed in the direction opposite that of the hns gene (i.e., clockwise on the E. coli chromosome) [1].
  • The nucleotide sequences of five galU mutations were also determined [1].
  • The amino-terminal amino acid sequence (10 residues) of the purified enzyme was identical to the predicted amino acid sequence (after the initiating methionine) of the galU-encoded open reading frame [1].
 

Chemical compound and disease context of galU

 

Biological context of galU

 

Analytical, diagnostic and therapeutic context of galU

  • A chromosomal hns gene was amplified with PCR consensus primers and localized near galU of E. amylovora [3].

References

  1. UTP: alpha-D-glucose-1-phosphate uridylyltransferase of Escherichia coli: isolation and DNA sequence of the galU gene and purification of the enzyme. Weissborn, A.C., Liu, Q., Rumley, M.K., Kennedy, E.P. J. Bacteriol. (1994) [Pubmed]
  2. Avirulence of rough mutants of Shigella flexneri: requirement of O antigen for correct unipolar localization of IcsA in the bacterial outer membrane. Sandlin, R.C., Lampel, K.A., Keasler, S.P., Goldberg, M.B., Stolzer, A.L., Maurelli, A.T. Infect. Immun. (1995) [Pubmed]
  3. Characterization of hns genes from Erwinia amylovora. Hildebrand, M., Aldridge, P., Geider, K. Mol. Genet. Genomics (2006) [Pubmed]
 
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