Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

lolB - lipoprotein localization factor

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1197, JW1200, hemM, ychC

Tanaka, K. et al., Matsuyama, S. et al., Verderber, E. et al., Ikemi, M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of lolB

Deletion of lolB, encoding an outer membrane lipoprotein, is lethal for Escherichia coli and causes accumulation of lipoprotein localization intermediates in the periplasm [1].

High impact information on lolB

An E.coli strain possessing chromosomal hemM under the control of the lac promoter-operator required IPTG for growth, indicating that hemM (lolB) is an essential gene [2].
To examine the in vivo function of LolB, we constructed a chromosomal lolB null mutant harboring a temperature-sensitive helper plasmid carrying the lolB gene [1].
We initiated these studies to help clarify the roles of heme, delta-aminolevulinic acid (ALA), hemA, and hemM in Escherichia coli heme synthesis [3].
The hemM gene was adjacent to hemA that is located at 27 min and previously thought to encode glutamyl-tRNA dehydrogenase [4].

References

Deletion of lolB, encoding an outer membrane lipoprotein, is lethal for Escherichia coli and causes accumulation of lipoprotein localization intermediates in the periplasm. Tanaka, K., Matsuyama, S.I., Tokuda, H. J. Bacteriol. (2001) [Pubmed]
A novel outer membrane lipoprotein, LolB (HemM), involved in the LolA (p20)-dependent localization of lipoproteins to the outer membrane of Escherichia coli. Matsuyama, S., Yokota, N., Tokuda, H. EMBO J. (1997) [Pubmed]
Role of the hemA gene product and delta-aminolevulinic acid in regulation of Escherichia coli heme synthesis. Verderber, E., Lucast, L.J., Van Dehy, J.A., Cozart, P., Etter, J.B., Best, E.A. J. Bacteriol. (1997) [Pubmed]
Cloning and characterization of genes involved in the biosynthesis of delta-aminolevulinic acid in Escherichia coli. Ikemi, M., Murakami, K., Hashimoto, M., Murooka, Y. Gene (1992) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.