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Gene Review

lolB  -  lipoprotein localization factor

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1197, JW1200, hemM, ychC
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Disease relevance of lolB

  • Deletion of lolB, encoding an outer membrane lipoprotein, is lethal for Escherichia coli and causes accumulation of lipoprotein localization intermediates in the periplasm [1].

High impact information on lolB

  • An E.coli strain possessing chromosomal hemM under the control of the lac promoter-operator required IPTG for growth, indicating that hemM (lolB) is an essential gene [2].
  • To examine the in vivo function of LolB, we constructed a chromosomal lolB null mutant harboring a temperature-sensitive helper plasmid carrying the lolB gene [1].
  • We initiated these studies to help clarify the roles of heme, delta-aminolevulinic acid (ALA), hemA, and hemM in Escherichia coli heme synthesis [3].
  • The hemM gene was adjacent to hemA that is located at 27 min and previously thought to encode glutamyl-tRNA dehydrogenase [4].


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