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Gene Review

thrA  -  Bifunctional aspartokinase/homoserine...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0002, Hs, JW0001, thrA1, thrA2, ...
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Disease relevance of thrA

  • In an attempt to express the two distal genes of the Escherichia coli threonine operon, the majority of the first gene in the operon, thrA, was removed and a series of transcriptional fusions were constructed placing the thrB and thrC genes downstream of either the trp or hybrid tac promoter [1].
  • The coding regions for the Escherichia coli gene for aspartokinase I/homoserine dehydrogenase I (thrA) and the Corynebacterium glutamicum gene for aspartic semialdehyde dehydrogenase (asd) have been subcloned into a Simian Virus 40 (SV40)-based mammalian expression vector [2].

High impact information on thrA


Chemical compound and disease context of thrA


Biological context of thrA


  1. Translational coupling in the threonine operon of Escherichia coli K-12. Little, S., Hyde, S., Campbell, C.J., Lilley, R.J., Robinson, M.K. J. Bacteriol. (1989) [Pubmed]
  2. The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell. Rees, W.D., Hay, S.M. Biochem. J. (1995) [Pubmed]
  3. Nucleotide sequence of the thrA gene of Escherichia coli. Katinka, M., Cossart, P., Sibilli, L., Saint-Girons, I., Chalvignac, M.A., Le Bras, G., Cohen, G.N., Yaniv, M. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  4. Nucleotide sequence of the metL gene of Escherichia coli. Its product, the bifunctional aspartokinase ii-homoserine dehydrogenase II, and the bifunctional product of the thrA gene, aspartokinase I-homoserine dehydrogenase I, derive from a common ancestor. Zakin, M.M., Duchange, N., Ferrara, P., Cohen, G.N. J. Biol. Chem. (1983) [Pubmed]
  5. Identification and characterization of mutants affecting transcription termination at the threonine operon attenuator. Lynn, S.P., Bauer, C.E., Chapman, K., Gardner, J.F. J. Mol. Biol. (1985) [Pubmed]
  6. Analysis of genomic sequences by Chaos Game Representation. Almeida, J.S., Carriço, J.A., Maretzek, A., Noble, P.A., Fletcher, M. Bioinformatics (2001) [Pubmed]
  7. Evidence for an internal promoter in the Escherichia coli threonine operon. Saint Girons, I., Margarita, D. J. Bacteriol. (1985) [Pubmed]
  8. Mutational analysis of the feedback sites of lysine-sensitive aspartokinase of Escherichia coli. Kikuchi, Y., Kojima, H., Tanaka, T. FEMS Microbiol. Lett. (1999) [Pubmed]
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