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Gene Review

pspA  -  regulatory protein for phage-shock-protein...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1299, JW1297, cog
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Disease relevance of pspA

  • The expression of specific PhoE mutant proteins leads to induction of the expression of the psp operon of Escherichia coli and the export of various plasmid-encoded precursors is retarded in a pspA mutant strain [1].
  • Truncated forms of PspA that are secreted from Streptococcus pneumoniae and their use in functional studies and cloning of the pspA gene [2].
  • Escherichia coli sigma54-dependent phage shock protein operon (pspA to -E) transcription is under the control of PspF, a constitutively active activator [3].

High impact information on pspA


Biological context of pspA

  • Molecular characterization of cog-192 revealed that it is a large chromosomal deletion extending from the 3' end of pspA through to the 5' end of an open reading frame located immediately upstream of ompG [5].


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