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Gene Review:

yccA - HflBKC-binding inner membrane protein,...

Escherichia coli str. K-12 substr. MG1655

McMurry, L.M. et al., Kihara, A. et al., Hardaway, K.L. et al., Rubin, R.A. et al., Schneider, A. et al.

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Disease relevance of yccA

Inner membrane vesicles prepared from susceptible Escherichia coli cells concentrated tetracycline 2.5 to 5 times above the external concentration when the electron transport substrate D-lactate or reduced phenazine methosulfate was added [1].
Inner membrane Tet proteins encoded by tet genes in gram-negative bacteria mediate resistance to tetracycline (Tcr) by directing its export [2].

High impact information on yccA

Inner membrane protease I, an enzyme mediating intramitochondrial protein sorting in yeast [3].
The mutation (yccA11) is an internal deletion within a gene (yccA) known as an open reading frame for a hydrophobic protein with putative seven transmembrane segments [4].
Inner membrane degradation was indicated by the release of beta-galactosidase, a cytoplasmic enzyme, and of trichloracetic acid-precipitable RNA [5].

References

Active uptake of tetracycline by membrane vesicles from susceptible Escherichia coli. McMurry, L.M., Cullinane, J.C., Petrucci, R.E., Levy, S.B. Antimicrob. Agents Chemother. (1981) [Pubmed]
Interdomain hybrid Tet proteins confer tetracycline resistance only when they are derived from closely related members of the tet gene family. Rubin, R.A., Levy, S.B. J. Bacteriol. (1990) [Pubmed]
Inner membrane protease I, an enzyme mediating intramitochondrial protein sorting in yeast. Schneider, A., Behrens, M., Scherer, P., Pratje, E., Michaelis, G., Schatz, G. EMBO J. (1991) [Pubmed]
Different pathways for protein degradation by the FtsH/HflKC membrane-embedded protease complex: an implication from the interference by a mutant form of a new substrate protein, YccA. Kihara, A., Akiyama, Y., Ito, K. J. Mol. Biol. (1998) [Pubmed]
Phospholipase activity in bacteriophage-infected Escherichia coli. III. Phopholipase A involvement in lysis of T4-infected cells. Hardaway, K.L., Maten, M.V., Buller, C.S. J. Virol. (1975) [Pubmed]

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